
NCBI . NLM . NIH . GOV {
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Title[redir]:
ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner - PMC
Description:
Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse microenvironmental stresses, including starvation, ER stress damages and exposure to ...
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Keywords {๐}
cells, atf, cell, xct, atfkd, figure, atfoe, tumor, expression, doi, death, significance, pubmed, google, scholar, growth, glioma, gliomas, brain, figures, pmc, human, erastin, germany, angiogenesis, ferroptosis, ttest, students, article, statistical, sorafenib, control, calculated, meansd, free, data, shown, promotes, glutamate, increased, analysis, found, compared, proliferation, effects, rsl, significantly, mrna, supplementary, fer,
Topics {โ๏ธ}
annexin v-positive/7-aad-negative cells annexin v-positive/7-aad-positive cells xct-specific inhibitors s-4-carboxy-phenylglycine cation-exchange resin-filled column xct blocker s-4-carboxy-phenylglycine uk/arrayexpress/experiments/e-mtab-3073/ anchorage-independent cell growth pmc beta search tumor-induced neuronal damage digital qrt-pcr procedure brain tumor-induced intoxication perk/eif2alpha/atf4 module full-length complementary dna atf4-induced tumor growth mem-based hbss medium gfp-positive u251 cells atf4-driving cell growth atf4-induced chemo-resistancy rsl3-induced cell death cabazitaxel operates anti-metastatic ferroptosis-mediated cell death kaplanโmeier survival analysis tumor-derived glutamate release iron-dependent cell death sorafenib-induced cell death glioma-induced brain edema erastin-induced cell death sirna-mediated xct silencing preventing rsl3-induced ferroptosis glutamate-free medium s-4-carboxy-phenylglycine atf4-mediated xct expression shrna-mediated atf4 knockdown xct/slc7a11 dependent manner atf4-overexpressing cells impaired organotypic brain slice promotes tumor growth cell death induced acquired chemo-resistance neuronal cell death atf4 expression fosters atf4 significantly reduced conjugated primary antibody atf4kd/xctoe media compared glutamate antiporter xct/scl7a11 er stress damages significantly prolonged g2/ 7 stress-dependent expression follow cytometer analysis rembrandt glioma dataset
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