We are analyzing https://link.springer.com/article/10.1007/s13238-021-00841-y.

Title:
Ferroptosis, radiotherapy, and combination therapeutic strategies | Protein & Cell
Description:
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,625,932 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

ferroptosis, pubmed, google, scholar, cancer, cas, cell, cells, central, lipid, tumor, death, slca, fig, protein, peroxidation, gpx, zhang, cellular, wang, expression, biol, rtinduced, role, radiation, liu, autophagy, iron, apoptosis, studies, radiotherapy, response, chen, lei, mechanisms, induces, damage, fins, promotes, radioresistance, stress, dna, activity, including, targeting, therapy, levels, activation, system, chem,

Topics {✒️}

phorbol-12-myristate-13-acetate-induced protein 1 cystine/glutamate transporter-deficient mice therapy-resistant high-risk neuroblastoma apoptosis-inducing factor-homologous mitochondrion kras-mutant lung adenocarcinoma anti-pd-1/pd-l1 combinations camp-response-element-binding protein hif-2ɑ activates hypoxia-induced slc7a11/xct-mediated cystine uptake cystine/glutamate antiporter system h-fsp1-coq axis acts h-fsp1-coq] signaling axis spermidine/spermine n1-acetyltransferase 1 rt-induced lung injury nf-e2–related factor 2 therapy-resistant high-mesenchymal article download pdf p53-inducible apoptogenic gene p53-inducible gene downregulated radiation-induced cell death suppresses acetyl-coa carboxylase amp-activated protein kinase prevent hydroperoxide-induced ferroptosis gpx4-independent defense systems p53-mediated ferroptotic responses lysophosphatidylcholine-induced cellular injury effective lipid-soluble antioxidant unstable carbon-centered radicals robust radical-trapping antioxidant pparα-mediated lipid remodeling cystine transporter slc7a11/xct system xc-mutant mice drug-resistant cancer cells induces caspase-independent apoptosis restraining pufa-pl biosynthesis b-raf proto-oncogene de la vega slc7a11-mediated cystine uptake inhibits rt-induced ferroptosis blocking pufa-pl synthesis glutathione-independent ferroptosis suppressor p53-null leukemic cells radiotherapy-induced cell death iron-dependent cell death ferroptosis-resistant cell state family member protein p53-mediated tumour suppression rt-mediated anticancer effects inhibited ir-induced ferroptosis experimental radiation oncology

Questions {❓}

Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A (2018) How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Kang R, Tang D (2016) What is the pathobiology of inflammation to cell death?
Rao SG, Jackson JG (2016) SASP: tumor suppressor or promoter?
Wang H, Jiang H, Van De Gucht M, De Ridder M (2019a) Hypoxic radioresistance: can ROS be the key to overcome it?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Ferroptosis, radiotherapy, and combination therapeutic strategies
         description:Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
         datePublished:2021-04-23T00:00:00Z
         dateModified:2021-04-23T00:00:00Z
         pageStart:836
         pageEnd:857
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s13238-021-00841-y
         keywords:
            ferroptosis
            lipid peroxidation
            GPX4
            SLC7A11
            radiotherapy
            immunotherapy
            radiosensitization
            combination therapy
            Biochemistry
            general
            Protein Science
            Cell Biology
            Stem Cells
            Human Genetics
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig5_HTML.png
         isPartOf:
            name:Protein & Cell
            issn:
               1674-8018
               1674-800X
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Higher Education Press
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Guang Lei
               affiliation:
                     name:Central South University
                     address:
                        name:Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chao Mao
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuelong Yan
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Li Zhuang
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Boyi Gan
               affiliation:
                     name:The University of Texas MD Anderson Cancer Center
                     address:
                        name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                        type:PostalAddress
                     type:Organization
                     name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences
                     address:
                        name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Ferroptosis, radiotherapy, and combination therapeutic strategies
      description:Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
      datePublished:2021-04-23T00:00:00Z
      dateModified:2021-04-23T00:00:00Z
      pageStart:836
      pageEnd:857
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s13238-021-00841-y
      keywords:
         ferroptosis
         lipid peroxidation
         GPX4
         SLC7A11
         radiotherapy
         immunotherapy
         radiosensitization
         combination therapy
         Biochemistry
         general
         Protein Science
         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13238-021-00841-y/MediaObjects/13238_2021_841_Fig5_HTML.png
      isPartOf:
         name:Protein & Cell
         issn:
            1674-8018
            1674-800X
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Higher Education Press
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Guang Lei
            affiliation:
                  name:Central South University
                  address:
                     name:Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chao Mao
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuelong Yan
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li Zhuang
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Boyi Gan
            affiliation:
                  name:The University of Texas MD Anderson Cancer Center
                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
                     type:PostalAddress
                  type:Organization
                  name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences
                  address:
                     name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Protein & Cell
      issn:
         1674-8018
         1674-800X
      volumeNumber:12
Organization:
      name:Higher Education Press
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Central South University
      address:
         name:Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson Cancer Center
      address:
         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
         type:PostalAddress
      name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences
      address:
         name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Guang Lei
      affiliation:
            name:Central South University
            address:
               name:Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Chao Mao
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Yuelong Yan
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Li Zhuang
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Boyi Gan
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences
            address:
               name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA

External Links {🔗}(437)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.48s.

LINK . SPRINGER . COM {}