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pubmed, google, scholar, article, cas, central, ferroptosis, cell, cancer, death, cells, chem, biol, iron, httpsdoiorgs, acid, lipid, inhibition, res, protein, chen, sci, inhibitor, httpsdoiorg, zhang, wang, med, pharmacol, lipoxygenase, liu, glutathione, mechanisms, biochem, oxidative, yang, mechanism, peroxidation, disease, factor, mitochondrial, stress, nat, species, activation, commun, effects, induced, sun, stockwell, kinase,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer oncogenic-ras-harboring cancer cells c-erbb2/her2/neu receptors s-n-butyl homocysteine sulfoximine tatiana cañeque & raphaël rodriguez p53-mediated ferroptotic responses 1-independent apoptosis-inducing factor jun n-terminal kinase friedmann angeli jp dna damage-inducing compounds month download article/chapter cystathionine-beta-synthase cd44 prevent hydroperoxide-induced ferroptosis renal nrk-52e cells apoptosis-inducing factor mitochondria rice-magnaporthe oryzae interactions hypoxia-induced gene activation myeloid-derived suppressor cells ferroptosis-mediated tissue injury iron-dependent cell death 4-dihydroxy-α-cyanocinnamate cdo1 renal-ischemia-reperfusion injury triple-negative breast cancer cytochrome-related sigma-2 receptor cancer cell-line profiling glutathione-independent ferroptosis suppressor erastin-induced cell death system xc−−deficient mice g93a-sod1 transgenic mice amyloid β-peptide toxicity raf kinase inhibitor express mutant ras trna-isopentenyl transferase required genotype-selective antitumor agents polyunsaturated fatty acids reduces plasma cholesterol cancer-acquired drug resistance voltage-gated sodium dependent gene expression reactive oxygen species α-eleostearic acid high-throughput screening ferroptotic cell death endoplasmic reticulum stress glutamate oxidative damage pancreatic cancer cells heart failure induced piper longum linn activating nrf2/ho-1 chaperone-mediated autophagy

Questions {❓}

• Feng H, Stockwell BR (2018) Unsolved mysteries: how does lipid peroxidation cause ferroptosis?

Schema {🗺️}

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      keywords:Small molecule, Iron, Fenton reaction, Reactive oxygen species, Lipid peroxidation
      description:Ferroptosis is a dedicated mode of cell death involving iron, reactive oxygen species and lipid peroxidation. Involved in processes such as glutathione metabolism, lysosomal iron retention or interference with lipid metabolism, leading either to activation or inhibition of ferroptosis. Given the implications of ferroptosis in diseases such as cancer, aging, Alzheimer and infectious diseases, new molecular mechanisms underlying ferroptosis and small molecules regulators that target those mechanisms have prompted a great deal of interest. Here, we discuss the current scenario of small molecules modulating ferroptosis and critically assess what is known about their mechanisms of action.
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