
NCBI . NLM . NIH . GOV {
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Title[redir]:
Golgi stress mediates redox imbalance and ferroptosis in human cells - PMC
Description:
Cytotoxic activities of several Golgi-dispersing compounds including AMF-26/M-COPA, brefeldin A and golgicide A have previously been shown to induce autophagy or apoptosis. Here, we demonstrate that these Golgi disruptors also trigger ferroptosis, a ...
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Keywords {๐}
cells, doi, cell, bfa, fig, golgi, ferroptosis, google, scholar, pubmed, treatment, hela, death, lipid, supplementary, pmc, free, article, slca, erastin, shown, knockdown, gpx, stress, treated, gsh, acsl, protein, levels, analysis, compounds, oxidative, response, control, glutathione, gca, sigmaaldrich, biol, cellular, peroxidation, pathway, medium, presence, cancer, relative, low, viability, effects, lines, survival,
Topics {โ๏ธ}
author contributions p62-keap1-nrf2 pathway protects anti-fas-mediated cell killing 4โ12% gradient sds-page competing interests q-vd-oph hydrate bfa/gca-induced cell death focus onbio-image informatics cis-golgi marker gm130 promote lipid peroxidation/ferroptosis37 iron-dependent oxidative degradation pmc beta search time-resolved phenotype annotation golgi stress-inducing agents 78-kda glucose-regulated protein neutral ฮฑ-amino acids lipid peroxide-detecting probe classical ferroptosis-inducing agent guanine nucleotide-exchange factors cystathionine-gamma-lyase function footnotes publisher golgi stress-induced redistribution bfa-induced golgi dispersal bfa-induced golgi-dispersal resist bfa-triggered ferroptosis bfa-induced cell death accggtatggctgacagccgggatcc cat-flag/xbai accggtatgagcctcggccgcctttgc gpx4-flag/ecori accggtatggcgacgaaggccgtgtgc sod1-flag/ecori accggtatgttgagccgggcagtgtgc sod2-flag/ecori pre-defined cellular masks cell type-specific manner5 golgi stress-inducing compounds called m-copa accggtatggtcagaaagcctgttgtg slc7a11-flag/ecori lentiviral-mediated knockdown studies cell death-inducing effect nutrient-deprived cancer cells li-cor odyssey scanner sd discussion golgi-dispersing compound dmem high-glucose media erโmitochondria encounter structure lentiviral hairpin-mediated depletion hepatocellular carcinoma cells tumor suppressor p53 flag-ฮณ-tubulin global brain ischemia lentiviral hairpin-mediated slc7a11 data availability statements
Questions {โ}
- Assuming lipid ROS formation is intrinsic to Golgi fragmentation, what might be the underlying molecular basis?
- The role of the Golgi apparatus in oxidative stress: is this organelle less significant than mitochondria?
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