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NATURE . COM {}

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We are analyzing https://www.nature.com/articles/s41423-019-0220-6.

Title:
Helper T cell differentiation | Cellular & Molecular Immunology
Description:
CD4+ T helper cells are key regulators of host health and disease. In the original model, specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs, but recent studies have revealed increasing complexities for CD4+ T-cell differentiation. Here, we first discuss CD4+ T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper cells. We next describe the mechanisms underlying CD4+ T-cell differentiation, including cytokine-induced signaling and transcriptional networks. We then review current and emerging topics of differentiation, including the plasticity and heterogeneity of T cells, the tissue-specific effects, and the influence of cellular metabolism on cell fate decisions. Importantly, recent advances in cutting-edge approaches, especially systems biology tools, have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.

Keywords {🔍}

pubmed, google, scholar, cas, cells, central, cell, immunol, nat, regulatory, differentiation, immunity, nature, helper, foxp, transcription, follicular, factor, interleukin, function, responses, control, metabolic, expression, med, development, effector, science, tcell, signaling, plasticity, lineage, regulates, human, gene, essential, article, access, rev, tbet, distinct, metabolism, fate, type, inflammation, exp, gata, controls, activation, transcriptional,

Topics {✒️}

permissions reprints privacy policy systems biology tools nature portfolio commensal-dendritic-cell interaction specifies manuscript editing important research area advertising long-lived virus-reactive memory research hospital tgf-beta-induced foxp3 inhibits social media runx/cbf beta binding raptor-mtorc1-mediated metabolic reprogramming author information authors establish t-reg-cell function intestinal border-dwelling bacteria transcription factor t-bet controls th2-specific expression scaling single-cell genomics transcription factors t-bet forkhead/winged-helix protein fork head-related protein proto-oncogene c-maf genome-wide crispr screens alpha-ketoglutarate-sensitive metabolic 1/t-fh fate bifurcation cd4+ t-cell differentiation single-cell rna-seq human skin-homing memory distinctive fat-treg phenotype author correspondence regulatory t-cell fate vivo-derived follicular nod/scid recipient mice hypoxia-inducible factors enhance cell-dependent iga responses t-fh cell differentiation regulatory t-cell functions including cytokine-induced signaling treat immune-mediated disease single-cell transcriptional responses springerlink instant access nature immunology 10 personal data il-4-induced th2 response tgf-beta-dependent suppression anti-pd-1 checkpoint blockade context-dependent gene programs sepsis-induced lung injury

Schema {🗺️}

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         Treg
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