
NCBI . NLM . NIH . GOV {
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Title[redir]:
CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs - PMC
Description:
Despite considerable research connecting cellular metabolism with differentiation decisions, the underlying mechanisms that translate metabolite-sensitive activities into unique gene programs are still unclear. We found that aspects of the ...
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Keywords {🔍}
cells, low, αkgsensitive, doi, ctcf, αkg, genes, cell, gene, high, figure, expression, pmc, pubmed, google, scholar, article, analysis, free, events, performed, conditions, differentiation, data, maintained, genome, metabolic, dna, sites, regions, peaks, primary, ilsensitive, methylation, gln, condition, programs, program, genomic, experiments, role, states, induced, effector, addition, chipseq, association, rnaseq, control, compared,
Topics {✒️}
gln analog 6-diazo-5-oxo-l-norleucine 6-diazo-5-oxo-l-norleucine sigma sjl-ptprca pepcb/boyj mice heatmap displaying z-scores sjl-ptprca pepcb/boyj t-box protein-mediated activation van der windt pmc beta search ctcf-chip-seq tracks chip-seq ctcf tracks hypoxia-inducible factors enhance unpaired student t-tests context-dependent manner depending α-ketoglutarate-sensitive metabolic intracellular alpha-ketoglutarate maintains context-dependent gene programs αkg-inducible ctcf peak plate-bound anti- cd3 plate-bound anti-cd3 αkg-sensitive ctcf peak il-2-sensitive regulatory elements αkg-sensitive ctcf site unpaired student t-test context-specific gene programs super-enhancers delineate disease h3k27-demethylase complex activity αkg-sensitive h3k27me3 peaks αkg-inducible ctcf peaks additional il-2-sensitive events prolonged interleukin-2ralpha expression h3k27ac chip-seq peaks ctcf chip-seq experiments αkg-sensitive metabolic programs ctcf chip-seq analysis ice-cold lysis buffer αkg-sensitive ctcf peaks il-2-sensitive gene programs αkg-sensitive mechanistic steps αkg-sensitive metabolic events star methods contact atac-seq atac-seq αkg-inducible gene expression αkg-sensitive metabolic states supplementary materials included transposase-accessible chromatin-sequencing peak read enrichment area-proportional venn diagrams references ballesteros-tato translate αkg-sensitive metabolic il-2-sensitive gene program
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