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Title[redir]:
Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression - PMC
Description:
Proteins of the nuclear factor of activated T cells (NFAT) family of transcription factors are critical for lymphocyte activation in the immune system. In particular, NFATs are important regulators of inducible IL-4 gene expression. Interferon ...
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Keywords {🔍}
irf, nfatc, cells, fig, nfat, promoter, expression, transcription, gene, activity, doi, interaction, pubmed, google, scholar, production, cell, transcriptional, factor, protein, proteins, mice, luciferase, dna, reporter, antibody, pmc, function, transfected, synergy, family, activation, binding, enhance, regulatory, article, glimcher, cmaf, endogenous, regulation, genes, complex, cytokine, conditions, free, interferon, important, naïve, role, association,
Topics {✒️}
multiple closely-linked nfat/octamer consensus sequence-binding protein agarose-conjugated anti-ha antibody 10 μg/ml anti–ifn-γ rel/nuclear factor kappab pmc beta search il-4-driven responses produced modulate nfat-driven induction th2-specific protein c-maf nfat-mediated gene expression interferon-regulated gene expression enhance nfat-mediated activation increase nfat-driven transactivation immune system–restricted member predicted α-helical structure nf-atp-deficient mice proto-oncogene c-maf enhance nfatc2-driven activation pmc copyright notice enhance il-2-luc activity il-4–inducing transcription factor anti-ha antibody resulted plate-bound anti-cd3 modulating nfat-dependent pathways putative α-helix deleted enhance nfatc2-mediated induction control anti-myc antibodies irf4-deficient mice supports consensus nfat site cell-type-restricted binding th2-specific transcription factor anti-nfatc2 polyclonal antibody irf4-nfatc2 protein–protein interactions weak dna-binding properties immunoglobulin light chain interferon-stimulated response element interferon regulatory factor il-4-luc promoter activity csa-sensitive enhancer region characterized nfat-binding sites th2-specific protein complex t-cell receptor stimulation 1 μg/ml anti-cd3 ha-irf4 expression plasmids high sequence homology 10 μg/ml anti–il-4 10 μg/ml anti–il-12 publisher site pdf hrp-conjugated irf4 antisera th2-cytokine producing cells
Questions {❓}
- What Might Be the Reasons for Differential Involvement of IRF4 and IRF8 with NFATc2?
- What might be the mechanism for the regulation of IL-4 by IRF4?
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