
NCBI . NLM . NIH . GOV {
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Title[redir]:
Late Developmental Plasticity in the T Helper 17 Lineage - PMC
Description:
Development of T helper (Th) 17 cells requires transforming growth factor (TGF)-β and interleukin (IL)-6 and is independent of the Th1 pathway. Although T cells that produce interferon (IFN)-γ are a recognized feature of Th17 cell responses, mice ...
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Keywords {🔍}
cells, doi, ifnγ, expression, ilf, ila, tgfβ, pubmed, google, scholar, mice, stat, figure, development, absence, cell, primer, thy, data, tbet, cytokine, conditions, pmc, effects, signaling, induction, induced, colitis, article, immunol, harrington, phenotype, presence, precursors, recovered, transfer, naive, transition, fraction, free, interleukin, reporter, autoimmune, ilb, ilrβ, isolated, immunity, expressed, sense, lineage,
Topics {✒️}
alexa-fluor-647-conjugated anti-il-17a microarray-based gene-expression analyses anti-il-12p40 administration caused pe-cy7-conjugated anti-cd4 ifn-γ-producing effectors arise pmc beta search transforming growth factor-beta recombineering-based gap repair single-positive ifn-γ cells tgf-β maintains il-17a rapidly upregulate ifn-γ tgf-β produced ifn-γ 10 μg/ml anti-ifn-γ il-12rβ1 chain binds il-17a− ifn-γ+ phenotype il-17a+ifn-γ+ cells ifn-γ+il-17a− cells constitutively expressed il-12rβ1 il-17-secreting t-helper phenotype t-bet-dependent transition marked conjugated anti-ifn-γ experimental procedures mice il-23-dependent programming related ifn-γ developed independently ifn-γ-dominated responses inhibit ifn-gamma expression th1-specific chemokine receptor enhances ifn-γ expression ifn-γ single-producers 5 ng/ml rhtgf-β1 continuous tgf-β availability undetectable ifn-γ+ cells t-bet-dependent manner th17-mediated pathogenesis paradigm expressed increased ifn-γ committed il-17-producing effectors il-17-producing effectors developed enhanced ifn-γ expression il-12 heterodimers—il-12p40 disrupted ifn-gamma gene ifn-γ enhancement appeared ifn-γ-producing cells transforming growth factor ifn-γ-producing progeny dominant ifn-γ expression stably express il-17a late immune-clearance mechanisms supplementary materials included ifn-γ-expressing cells fitc-conjugated anti-cd45rb
Questions {❓}
- Why has the Th17 lineage evolved to enable a shift from dominant IL-17 to dominant IFN-γ expression?
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