NCBI . NLM . NIH . GOV {
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Title[redir]:
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription - PMC
Description:
T helper type 1 (Th1) development is facilitated by interrelated changes in key intracellular factors, particularly signal transducer and activator of transcription (STAT)4, T-bet, and GATA-3. Here we show that CD4+ cells from T-betā/ā mice are ...
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Keywords {š}
cells, tbet, conditions, gata, expression, stat, mice, ifnĪ³, ilrĪ², naive, chain, wildtype, stimulated, shown, retroviral, day, studies, differentiation, levels, cell, pubmed, google, scholar, doi, fig, data, optimal, suboptimal, ifng, production, antiil, obtained, signaling, expressing, results, normal, developing, cytokine, cultured, independent, analysis, tbetexpressing, protein, effect, promoter, antibody, experiments, pmc, retrovirus, anticdanticd,
Topics {āļø}
plate-bound anti-cd3/soluble anti-cd28 org/cgi/content/full/jem anti-cd3/soluble anti-cd28 involving ifn-Ī³/stat1/t-bet conserved t-box half-site dominant-negative t-bet construct antiāmouse ifn-Ī³ antibody plate-bound anti-cd3 rq1 rnaseāfree dnase induces ifn-Ī³ production t-betā/ā effectorāmemory cd4+ anti-cd3/anti-cd28 anti-cd3/ anti-cd28 pmc beta search il-12rĪ²2 chain occurs intra-cellular cytokine staining express il-12rĪ²2 chain t-betāindependent th1 development t-betāexpressing retrovirus retrovirus expressing t-bet subsequent ifn-Ī³/stat1 signaling antiāmouse cd62l microbeads expressing retroviral t-bet il-12rĪ²2 chain staining t-betāexpressing retroviruses retroviruses expressing t-bet il-12rĪ²2 chain expression pmc copyright notice expressed retroviral t-bet real-time rt-pcr il-12rĪ²2 chain stain ifn-Ī³ production displayed retroviral t-bet expression cell-specific activator protein providing t-betā/ā mice antiāmouse cd4 microbeads online supplemental material cells expressing ifn-Ī³ stat4/il-12rĪ²2 chain t-bet suppresses il-4 t-bet suppresses gata-3 real-time pcr analysis undergo th1/th2 differentiation factors including t-bet induce t-bet expression soluble anti-cd28 t-bet protein expression plate-bound cd3 t-betā/ā cells arises t-betā/ā cells grow
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