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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3108066/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3108066/. The analysis below is for the second page.
Title[redir]:
Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling - PMC
Description:
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1–4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and ...
Title[redir]:
Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling - PMC
Description:
CD4+ T cells that selectively produce interleukin (IL)-17, are critical for host defense and autoimmunity1–4. Crucial for T helper17 (Th17) cells in vivo5,6, IL-23 has been thought to be incapable of driving initial differentiation. Rather, IL-6 and ...
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Keywords {🔍}
cells, doi, tgfβ, fig, pubmed, google, scholar, expression, differentiation, tbet, supplementary, data, mice, pmc, absence, ilr, interleukin, thβ, article, cell, ilβ, naïve, immunol, free, induced, rorγt, nature, cytokines, antibodies, nat, pathogenic, signaling, helper, vivo, production, ila, shown, mrna, analyzed, inflammation, nlm, generated, present, ilproducing, experiments, expressed, rorc, eae, disease, numbers,
Topics {✒️}
naive cd4+cd62l+cd44−cd25− population plate-bound anti-cd3/anti-cd28 tgf-β/il-6/il-1β-induced th17 cells plate-bound anti-cd3/cd28 anti-cd3/anti-cd28 antibodies anti-ifn-γ neutralizing antibodies anti-tgf-β neutralizing antibodies il-23/il-6/il-1β-induced expression naïve cd4+vβ11+cd62l+cd44− natural cd4+cd25+foxp3+ regulatory tgfbr1fl+cd4-cre+ littermate controls anti-cd3/anti-cd28 il-6/il-1β induced differentiation transforming growth factor-beta il-17-producing ot-ii cd4+ rorγt+ t-bet+ il-17+cd4+ tgf-β1/il-6/il-1β anti-tgf-β antibodies t-bet+rorγt+ th17 cells pmc beta search tgf-β-independent th17 differentiation th17-driven inflammatory disease ifn-γ-producing cd4+ il-17-producing cells induced il-23 upregulates il-23r transforming growth factor il-23/il-6/il-1β tgfbr1f/+cd4-cre+ littermates impaired tgf-β signaling antagonizing tgf-β-signaling age-matched wild type tgf-β1 inhibited expression il-17-producing cells helps il-23-mediated il-22 production tgf-β-dependent differentiation endogenously produced tgf-β primary inductive factor il-23-induced th17 cells cns expressed t-bet il-23-dependent th17 differentiation blocking tgf-β1 resulted tgfbr1f/fcd4-cre+ mice il-17-producing cd4+ cells anti-h3k9m3 antibodies cns-infiltrating mononuclear cells enhanced il-2-production cd4-cre−transgenic mice serum-free media foxp3+ natural regulatory transcription factor expression
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