
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Critical regulation of early Th17 cell differentiation by IL-1 signaling - PMC
Description:
Th17 cells have been recently discovered in both mouse and human. Although IL-1 has been shown to be important in human Th17 cell differentiation with little knowledge of the underlying mechanism, its function in mouse is less clear. Here we show ...
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Keywords {🔍}
cells, doi, mice, ilr, expression, differentiation, foxp, figure, cell, tgfβ, scholar, pubmed, google, signaling, irf, data, shown, naïve, rorγt, pmc, yang, presence, early, eae, population, article, cytokines, polarization, staining, anticd, absence, free, nature, cytokine, induction, intracellular, role, study, higher, analyzed, day, required, compared, treg, vivo, observed, days, production, generation, ilproducing,
Topics {✒️}
pe-conjugated anti-t-bet ab plate-bound anti-cd3 ab il-1r1-deficient ot-ii mice yield il-1r1−/−ot-ii mice real-time rt-pcr cell-depleted bone-marrow cells added anti-il-1r1 ab 5 μg/ml anti-ifn-γ plate-bound anti-cd3 mixed bone-marrow chimeras facs-sorted naïve ot-ii real-time pcr analysis references acosta-rodriguez ev bone-marrow derived dcs transforming growth factor-beta tgf-beta-induced foxp3 inhibits generated mixed bone-marrow anti-il-4/anti-ifnγ abs anti-cd3/cd28 stimulated differentiation mixed bm-chimeric mice anti-cd3/cd28 ab anti-cd3/cd28 abs il-17f-rfp reporter mice soluble anti-cd3 ab pmc beta search 2 mg/ml anti-cd3 il-17-producing wt ot-ii 1 μg/ml anti-cd28 real-time pcr facs-sorted cd4+gfp+ cells th17-mediated autoimmune disorder il-1r1 delivers signal naive ot-ii cd4+ anti-il-1r1ab treatment anti-il-4/anti-ifnγabs anti-il-1r1 ab il-1r1 blocking ab wild-type ot-ii anti-cd3 restimulation showed anti-tgf-β ab 5 μg/ml anti-il-4 ifn-γ-expressing cells il-1r-accessory protein retroviruses expressing irf4-gfp naive cd4+cd25− cd62lhicd44lo naive cd4+cd25−cd62lhicd44lo il-1ra-deficient mice foxp3-gfp reporter mice t-bet-expressing cells 10 ng/ml il-1β
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