
NCBI . NLM . NIH . GOV {
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Title[redir]:
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer - PMC
Description:
Interferon γ (IFNγ) is the hallmark cytokine produced by T helper type 1 (Th1) cells, whereas interleukin (IL)-4 is the hallmark cytokine produced by Th2 cells. Although previous studies have revealed the roles of cytokine signaling and of ...
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Keywords {🔍}
cells, runx, expression, mice, fig, silencer, differentiation, cbfβ, cell, doi, protein, antibody, pubmed, google, scholar, complexes, cbfβff, naive, gata, gene, results, pmc, binding, function, development, transcription, loss, article, control, thymocytes, cytokine, tbet, chip, jexpmedjemjemfsjpg, jpg, ifnγ, inactivation, proteins, data, nlm, repression, complex, derepression, detected, factor, silencing, lane, representative, free, factors,
Topics {✒️}
org/cgi/content/full/jem pmc beta search purified cd4+cd25−cd62l+ naive loxp-flanked coding exon t-cell subset-specific expression t-bet–dependent runx3 expression key trans-acting factors combined cis-regulatory elements generated loxp-flanked cbfβfllox soluble anti-cd28 antibody il-4/ifnγ double producers naive cd4+cd25−cd62l+ important cis-regulatory region pmc copyright notice online supplemental material immobilized anti-cd3 antibody anti-cbfβ2 antibody failed transcription factors t-bet soluble anti-cd28 antibodies conserved dna-binding domain distal promoter–derived runx1 asthma-related symptoms caused impaired th1-mediated immunity cd4-cre transgenic mice providing anti-runx3 antibody cd4+cd8int phenotype resulting cd4+cd8+ dp stages cre-mediated recombination cbfβ-deficient naive cd4+ supplementary materials included publisher site pdf ifnγ-producing th1 cells transcription factor gata-3 il-4–producing th2 cells license information pmcid core binding factor hs iv site mouse genome led th2-mediated responses immobilized anti-cd3 induced t-bet cd8+ cytotoxic-lineage cells asthma-related symptoms runx complexes play promoter–derived runx1 southern blot analyses increased il4 transcription anti-runx3 antibody th1 development mediated nonprecipitated input dna
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