NCBI . NLM . NIH . GOV {
}
We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3182542/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3182542/. The analysis below is for the second page.
Title[redir]:
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response - PMC
Description:
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self-tolerance. We describe a population of ...
Title[redir]:
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response - PMC
Description:
Follicular helper (TFH) cells provide crucial signals to germinal center B cells undergoing somatic hypermutation and selection that results in affinity maturation. Tight control of TFH numbers maintains self-tolerance. We describe a population of ...
Matching Content Categories {📚}
- Science
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Custom-built
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
cells, tfr, doi, tfh, treg, germinal, mice, fig, foxp, center, cell, pubmed, google, scholar, immunization, bcl, days, regulatory, control, expression, supplementary, pmc, blimp, follicular, article, formation, free, nature, helper, response, differentiation, figure, srbc, foxpdtr, function, expressed, chimeras, immunized, shdafoxp, represent, flow, science, naïve, centers, proportion, plots, required, contour, panel, numbers,
Topics {✒️}
cd4+cd44highcxcr5int/lowpd-1int/lowfoxp3− effector/memory cd4+cd44intcxcr5int/lowpd-1int/lowfoxp3+ regulatory rosa-stop-flox-yfp mice immunized rosa-stop-flox-yfp mice alum-precipitated np-chicken gammaglobulin splenic cd4+cxcr5highpd-1high cells cd4+cxcr5highpd-1highfoxp3+ follicular regulatory cd4+cxcr5highpd-1high tfh cells pmc beta search cd4+cxcr5highpd-1highfoxp3+ tfr cells cd4+cxcr5highpd-1high compartment 2+cd4+cxcr5highpd-1high cells cd4+cxcr5highpd-1high cells long-lived plasma cells antigen-specific antibody response antibody-forming cell compartments anti-np antibody titers donor-origin naïve cells cxcr5highpd-1highcd4+ ‘tfh’ compartment t-dependent immune reaction fewer antigen-specific cells np-specific splenic memory antigen-specific germinal center cxcr5highpd-1highcd4+ cells express mann whitney u-test follicular t-helper cells cd4+cxcr5highpd-1highfoxp3− quantitative rt-pcr revealed foxp3-dependent manner repress thymic-derived foxp3+ precursors cxcr5highpd-1high cells dt-treated mice displayed long-term impact grey contour plots t-dependent antigen ot-ii transgenic donor-origin tfr donor-origin treg secondary lymphoid tissues bone marrow cells grey histograms represent tfh effector/memory cells immunized cd40l-deficient mouse lister prize fellowship t-dependent antigens antigen specific clones antigen-specific clones x-linked syndrome cell peripheral homeostasis grey histogram represents
Questions {❓}
- The observation that TFR require the same cues as TFH for their differentiation raised a critical question: do TFR represent induced Treg that arise from TFH cells that switch on Foxp3 in the germinal center, or do they derive from Foxp3+ Treg?
Social Networks {👍}(6)
External Links {🔗}(113)
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