
NCBI . NLM . NIH . GOV {
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Title[redir]:
HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells - PMC
Description:
HIF1α induction by mTOR represents a metabolic checkpoint for the differentiation of TH17 and Treg cells.
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Keywords {🔍}
cells, hifα, cell, differentiation, fig, treg, expression, glycolytic, mice, naive, google, scholar, doi, pubmed, conditions, foxp, pmc, metabolic, activity, data, article, free, glycolysis, effector, mtor, differentiated, represent, independent, experiments, gene, rapamycin, induction, metabolism, staining, molecules, analyses, pathway, generation, realtime, pcr, mog, signaling, presence, levels, nature, immunol, regulatory, glucose, intracellular, treatment,
Topics {✒️}
myelin oligodendrocyte glycoprotein phorbol 12-myristate 13-acetate isolated draining ln hypoxia-inducible factor-1alpha hypoxia-inducible factor 1alpha glucose analogue 2-deoxyglucose org/cgi/content/full/jem ot-ii tcr-transgenic mice glucose transport 1 tgf-beta-induced foxp3 inhibits specific pathogen-free conditions activation-inducible short isoform 10 µg/ml anti–ifn-γ pmc beta search real-time pcr analyses cell-mediated immune suppression hif1α–mediated metabolic reprogramming pmc copyright notice treg cell–inducing conditions cell-free sample hif1α–dependent metabolic reprogramming polyclonal anti–hif1α antibody plate-bound anti-cd3 2 µg/ml anti-cd28 2 ng/ml tgf-β1 hif1α–dependent transcriptional program 10 ng/ml tgf-β 1 ng/ml tgf-β hif1α–induced metabolic reprogramming cd4-cre transgenic mice th17-polarized transfer model transcription factors/signaling pathways pleiotropic cytokine tgf-β 2 µg/ml anti-cd3 transcription factor hif1α hif1α–dependent glycolytic pathway amino acid uptake lipid-activated nuclear receptors amino acid metabolism 10 µg/ml anti–il-4 10 µg/ml anti–il-2 antagonizes ror-γt function antagonize ror-γt function amino acid depletion real-time pcr ben-shoshan publisher site pdf rapamycin-sensitive mtor signaling th17-polarized transfer eae th17-dependent cns inflammation
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