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We are analyzing https://www.nature.com/articles/s41392-022-00955-7.

Title:
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention | Signal Transduction and Targeted Therapy
Description:
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, that are associated with the inflammatory response, have been implicated within atherosclerosis such as NLRP3 inflammasome, toll-like receptors, proprotein convertase subtilisin/kexin type 9, Notch and Wnt signaling pathways, which are of importance for atherosclerosis development and regression. Targeting inflammatory pathways, especially the NLRP3 inflammasome pathway and its regulated inflammatory cytokine interleukin-1β, could represent an attractive new route for the treatment of atherosclerotic diseases. Herein, we summarize the knowledge on cellular participants and key inflammatory signaling pathways in atherosclerosis, and discuss the preclinical studies targeting these key pathways for atherosclerosis, the clinical trials that are going to target some of these processes, and the effects of quelling inflammation and atherosclerosis in the clinic.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Health & Fitness
  • Science
  • Education

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Custom-built

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What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 41,362,249 visitors per month in the current month.

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Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$521,200 per month
Our calculations suggest that Nature.com earns between $347,485 and $955,583 monthly online from display advertisements.

Keywords {🔍}

pubmed, article, google, scholar, cas, atherosclerosis, cells, central, cardiovascular, nlrp, patients, signaling, inflammasome, cell, disease, inflammation, atherosclerotic, pcsk, activation, vascular, risk, notch, inflammatory, clinical, role, macrophages, mice, vsmcs, development, receptor, expression, studies, pathways, treatment, plaque, cholesterol, wnt, levels, protein, effects, therapeutic, pathway, med, res, biol, immune, type, smooth, muscle, tlr,

Topics {✒️}

nature portfolio privacy policy ros/nf-κb/lox-1/oxldl axis activated flagellin-tlr5-nox4 axis promotes c-jun n-terminal kinase advertising cryopyrin/nalp3 binds atp/datp unconventional g-protein-coupled receptors ckii-sirt1-sm22alpha loop evokes decreased ankle-brachial index high-sensitivity c-reaction protein human glp-1amino-acid sequences p-selectin antagonist inclacumab peroxisome proliferator-activated receptor-α systemic immune-inflammation index flow-dependent anti-apoptotic gene angiotensin ii-induced therosclerosis ankle brachial index wnt/β-catenin signaling sclerostin carotid intima-media thickness processes pro-il-1β/pro-il-18 reprints cysteine-rich angiogenesis inducer anti-inflammatory cytokines tgf-β apoa-i-knockout mouse plasma plasma cell-immunoglobulin-dependent mechanisms canonical wnt/β-catenin pathway serine/threonine kinase akt/enos tgf-β-dependent tolerance phenotype wnt/β-catenin signaling pathway smooth muscle 22alpha t-cell subsets controls india single-cell rna-sequencing combination mer tyrosine-protein kinase adaptor inducing interferon-beta peroxisome proliferator-activated receptor process directly pro-il-1β pro-il-1β/pro-il-18 nlrp3-mediated il-1β production suppressing ros/nuclear factor low-density lipoprotein cholesterol single-cell proteomics combined t-lymphocyte subpopulations related single-cell rna-sequencing ligand-gated ion channels large-scale clinical trial pre-β hdl levels bridging jagged1-notch3 signaling potently inhibits atp-triggered

Questions {❓}

  • Antioxidants in the fight against atherosclerosis: is this a dead end?
  • Inclisiran: a game changer in a changing game?
  • Natural killer cells: friend or foe in metabolic diseases?
  • Phospholipase A2 is an inflammatory predictor in cardiovascular diseases: is there any spacious room to prove the causation?
  • Atherosclerosis: gone with the Wnt?

Schema {🗺️}

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      headline:Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
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