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         headline:Efficacy and Safety of Mipomersen: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
         description:Our aim was to assess the efficacy and safety of mipomersen through a systematic review of the literature and a meta-analysis of the available clinical studies. A systematic literature search in SCOPUS, PubMed Medline, ISI Web of Science and Google Scholar databases was conducted up to January 20, 2019, in order to identify clinical trials assessing the effect of mipomersen on lipoproteins, and the safety profile of mipomersen. Effect sizes for lipid changes were expressed as weighted mean differences (WMD) and 95% confidence intervals (CI). For safety analysis, odd ratios (OR) and 95% CI were calculated using the Mantel–Haenszel method. Data were pooled from 13 clinical studies comprising 49 arms, which included 1053 subjects overall, with 729 in the active-treated arm and 324 in the control arm. Meta-analysis of data suggested that mipomersen significantly reduced low-density lipoprotein cholesterol (WMD − 1.52, 95% CI − 1.85 to − 1.19; p < 0.001), total cholesterol (WMD − 1.55, 95% CI − 1.97 to − 1.13; p < 0.001), non-high-density lipoprotein cholesterol (non-HDL-C) (WMD − 1.66, 95% CI − 2.06 to − 1.27; p < 0.001), lipoprotein(a) (WMD − 0.99, 95% CI − 1.37 to − 0.62; p < 0.001), apolipoprotein B (WMD − 1.66, 95% CI − 2.04 to − 1.27; p < 0.001), triglycerides (WMD –0.61, 95% CI − 0.76 to − 0.46, p < 0.001), very-low-density lipoprotein cholesterol (WMD − 0.58, 95% CI − 0.73 to − 0.43; p < 0.001) and apolipoprotein A-I (WMD − 0.25, 95% CI − 0.51 to − 0.001; p = 0.049) without affecting HDL-C levels (WMD 0.11, 95% CI − 0.03 to 0.26; p = 0.124). However, treatment with mipomersen was positively associated with an increased risk of discontinuation of treatment (OR 3.02, 95% CI 1.96–4.65; p < 0.001), injection-site reaction (OR 11.41, 95% CI 7.88–16.52; p < 0.001), hepatic steatosis (OR 4.96, 95% CI 1.99–12.39; p = 0.001), hepatic enzymes elevation (OR 3.61, 95% CI 2.09–6.24; p < 0.001) and flu-like symptoms (OR 2.02, 95% CI 1.45–2.81; p < 0.001). Despite favourable effects on the lipid profile, some concerns are reinforced from the safety profile. As a matter of fact, mipomersen therapy is more likely discontinued and associated with increased risk of injection-site reactions, hepatic steatosis, hepatic enzyme elevation, and flu-like symptoms.
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      headline:Efficacy and Safety of Mipomersen: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
      description:Our aim was to assess the efficacy and safety of mipomersen through a systematic review of the literature and a meta-analysis of the available clinical studies. A systematic literature search in SCOPUS, PubMed Medline, ISI Web of Science and Google Scholar databases was conducted up to January 20, 2019, in order to identify clinical trials assessing the effect of mipomersen on lipoproteins, and the safety profile of mipomersen. Effect sizes for lipid changes were expressed as weighted mean differences (WMD) and 95% confidence intervals (CI). For safety analysis, odd ratios (OR) and 95% CI were calculated using the Mantel–Haenszel method. Data were pooled from 13 clinical studies comprising 49 arms, which included 1053 subjects overall, with 729 in the active-treated arm and 324 in the control arm. Meta-analysis of data suggested that mipomersen significantly reduced low-density lipoprotein cholesterol (WMD − 1.52, 95% CI − 1.85 to − 1.19; p < 0.001), total cholesterol (WMD − 1.55, 95% CI − 1.97 to − 1.13; p < 0.001), non-high-density lipoprotein cholesterol (non-HDL-C) (WMD − 1.66, 95% CI − 2.06 to − 1.27; p < 0.001), lipoprotein(a) (WMD − 0.99, 95% CI − 1.37 to − 0.62; p < 0.001), apolipoprotein B (WMD − 1.66, 95% CI − 2.04 to − 1.27; p < 0.001), triglycerides (WMD –0.61, 95% CI − 0.76 to − 0.46, p < 0.001), very-low-density lipoprotein cholesterol (WMD − 0.58, 95% CI − 0.73 to − 0.43; p < 0.001) and apolipoprotein A-I (WMD − 0.25, 95% CI − 0.51 to − 0.001; p = 0.049) without affecting HDL-C levels (WMD 0.11, 95% CI − 0.03 to 0.26; p = 0.124). However, treatment with mipomersen was positively associated with an increased risk of discontinuation of treatment (OR 3.02, 95% CI 1.96–4.65; p < 0.001), injection-site reaction (OR 11.41, 95% CI 7.88–16.52; p < 0.001), hepatic steatosis (OR 4.96, 95% CI 1.99–12.39; p = 0.001), hepatic enzymes elevation (OR 3.61, 95% CI 2.09–6.24; p < 0.001) and flu-like symptoms (OR 2.02, 95% CI 1.45–2.81; p < 0.001). Despite favourable effects on the lipid profile, some concerns are reinforced from the safety profile. As a matter of fact, mipomersen therapy is more likely discontinued and associated with increased risk of injection-site reactions, hepatic steatosis, hepatic enzyme elevation, and flu-like symptoms.
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