
NCBI . NLM . NIH . GOV {
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Title[redir]:
PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis - PMC
Description:
The aim of the study was to study a nanoliposomal anti-PCSK9 vaccine as a novel approach for cholesterol lowering via PCSK9 inhibition. An immunogenic peptide construct termed immunogenic fused PCSK9-tetanus (IFPT) was displayed on the surface of ...
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Keywords {🔍}
mice, pcsk, doi, vaccine, control, lifpta, google, scholar, ldlc, group, pubmed, vaccinated, atherosclerosis, plasma, antibodies, hypercholesterolemic, levels, figure, cbl, ldlr, cholesterol, antibody, study, antipcsk, peptide, weeks, significant, cells, compared, ifpta, longterm, vaccination, pmc, lifpt, titers, ifpt, formulations, lesions, cell, analysis, data, approach, free, lesion, hypercholesterolemia, nanoliposomal, vaccines, groups, model, liposomal,
Topics {✒️}
a-q-y-i-k-a-n-s-k-f-i-g-i-t-e s-i-p-w-n-l-e-r-i-t-p-v 2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[maleimide hrp-conjugated anti-ldlr pro-inflammatory ifn-γ cytokine peptide-based anti-pcsk9 vaccines apolipoprotein-e-deficient mice apolipoprotein e-knockout mice 2-dimyristoyl-sn-glycero-3-phosphorylglycerol 2-dimyristoyl-sn-glycero-3-phosphorylcholine liposomal anti-pcsk9 vaccine low-density lipoprotein cholesterol increased anti-inflammatory response high-density lipoprotein cholesterol nanoliposomal anti-pcsk9 vaccine subtypes showing pro-atherogenic anti-inflammatory th2 cells vaccine-based pcsk9 suppression vaccine-provoked pcsk9 antibodies l-ifpta+ vaccine induced l-ifpta+ vaccine exhibited peptide-based antipcsk9 vaccines proprotein convertase subtilisin l-ifpta+ vaccine inhibited anti-pcsk9 vaccine formulations pmc beta search functional pcsk9-specific antibodies anti-β actin antibody vaccine-generated antibodies e-stained grade l-ifpta+ vaccine group peptide-based active vaccination pre-vaccination time point p-407-induced mouse model placebo-controlled descartes study l-ifpta+-vaccinated mice compared safe pcsk9-specific antibodies lipid-film hydration approach construct vaccine formulation fda-approved pcsk9 mabs l-ifpta+ vaccine resulted long-term statin therapy vitro pcsk9-ldlr binding long-term ldlc management l-ifpta+ vaccine observed inf-γ cytokine level anti-inflammatory cells greatest igg titers suppress pcsk9-ldlr interaction vaccine-induced antibodies
Questions {❓}
- How do we improve patient compliance and adherence to long-term statin therapy?
- New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?
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