We are analyzing https://link.springer.com/article/10.1007/s40265-019-1057-0.

Title:
Emerging Role of SGLT-2 Inhibitors for the Treatment of Obesity | Drugs
Description:
Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductions in body weight and adiposity. The ability to reduce body weight is consistently observed in individuals taking SGLT2 inhibitors, but this weight loss is moderate due to counter-regulatory mechanisms striving to maintain body weight. This has prompted exploration of SGLT2 inhibitors in combination with other agents acting via decreased food intake, e.g., glucagon-like peptide 1 receptor agonists (GLP1-RAs). The bodyweight effects are promising, and together with the signs of prevention of cardiovascular and renal events, such combinations including SGLT2 inhibitors are appealing. The weight loss is clinically important, as most individuals with type 2 diabetes are overweight or obese, but also because there is an unmet need for safe, effective, and durable weight loss interventions in obese individuals without diabetes.
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Keywords {🔍}

diabetes, pubmed, sglt, article, google, scholar, inhibitors, cas, weight, type, patients, loss, dapagliflozin, obese, effects, combination, obesity, glucose, therapy, treatment, body, cardiovascular, study, metab, subjects, inhibitor, trial, central, obes, renal, metformin, insulin, blood, efficacy, reduction, monotherapy, studies, controlled, safety, randomized, canagliflozin, pressure, individuals, bodyweight, clinical, med, reduce, intake, week, nct,

Topics {✒️}

int/mediacentre/factsheets/fs311/en/ article download pdf uncontrolled open-label extension long-term weight maintenance counter-regulatory mechanisms striving physiological counter-regulatory mechanisms long-term trials designed active-controlled noninferiority trial short-term weight loss peptide-1-induced insulin secretion address counter-regulatory mechanisms long-term cardiovascular events long-term glycaemic response post-meal glucagon concentrations diet-induced obese mice empa-reg outcome study low-grade chronic inflammation additional glucose-lowering therapies selective sodium-glucose drug-naive asian patients total fat mass growing health issue placebo-controlled 102-week trial reduce arterial stiffness bailey cj privacy choices/manage cookies ly3298176 glp1 + gip-ra [78] effective weight-loss therapies mearns es body fat mass randomized double-blind trial frias jp weight loss induced endocrinology position statement regulate endogenous production glomerular filtration rate blood glucose levels wiviott sd fat mass reduction empa-reg outcome diet-induced obese metformin-based combination therapy leibel rl glp-1 receptor agonist gerich je peptide-1 receptor agonists real world analysis plasma glucose concentration plasma glucose drops meta-analyses show

Questions {❓}

Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study?
Does GLP-RA Plus an SGLT2 Inhibitor Yield Greater Weight Loss in Patients with Obesity and Diabetes than Monotherapy?

Schema {🗺️}

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         headline:Emerging Role of SGLT-2 Inhibitors for the Treatment of Obesity
         description:Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductions in body weight and adiposity. The ability to reduce body weight is consistently observed in individuals taking SGLT2 inhibitors, but this weight loss is moderate due to counter-regulatory mechanisms striving to maintain body weight. This has prompted exploration of SGLT2 inhibitors in combination with other agents acting via decreased food intake, e.g., glucagon-like peptide 1 receptor agonists (GLP1-RAs). The bodyweight effects are promising, and together with the signs of prevention of cardiovascular and renal events, such combinations including SGLT2 inhibitors are appealing. The weight loss is clinically important, as most individuals with type 2 diabetes are overweight or obese, but also because there is an unmet need for safe, effective, and durable weight loss interventions in obese individuals without diabetes.
         datePublished:2019-01-30T00:00:00Z
         dateModified:2019-01-30T00:00:00Z
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      headline:Emerging Role of SGLT-2 Inhibitors for the Treatment of Obesity
      description:Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductions in body weight and adiposity. The ability to reduce body weight is consistently observed in individuals taking SGLT2 inhibitors, but this weight loss is moderate due to counter-regulatory mechanisms striving to maintain body weight. This has prompted exploration of SGLT2 inhibitors in combination with other agents acting via decreased food intake, e.g., glucagon-like peptide 1 receptor agonists (GLP1-RAs). The bodyweight effects are promising, and together with the signs of prevention of cardiovascular and renal events, such combinations including SGLT2 inhibitors are appealing. The weight loss is clinically important, as most individuals with type 2 diabetes are overweight or obese, but also because there is an unmet need for safe, effective, and durable weight loss interventions in obese individuals without diabetes.
      datePublished:2019-01-30T00:00:00Z
      dateModified:2019-01-30T00:00:00Z
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      name:Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
      name:Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden

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