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Keywords {🔍}

mirp, group, mice, wnta, plaque, article, agomir, expression, content, google, scholar, aortic, atherosclerosis, staining, apoe, oewnta, lipid, cells, serum, study, cas, decreased, comparison, red, tissues, muscle, fig, area, antagomir, smooth, cell, collagen, multiple, contents, βcatenin, macrophages, positive, percentage, comparisons, signaling, data, levels, china, normal, groups, mda, results, raised, analysis, pathway,

Topics {✒️}

mir-342-5p agomir + oe-wnt3a group rna-free phosphate-buffered saline macrophage-derived mir-342-5p facilitates microrna-99a-5p alleviates atherosclerosis wnt3a/beta-catenin signaling pathway enzyme-linked immunosorbent assay 40 mg/kg mir-342-5p agomir sigma-aldrich chemical company 100 pm mir-342-5p agomir impaired wnt-lrp6 signaling high-density lipoprotein cholesterol specific pathogen-free grade macrophage-derived mir-342-5p wnt3a activates beta1-integrin low-density lipoprotein cholesterol quanzhong hu mir-342-5p agomir concentration highly expressed mir-342-5p mir-342-5p/wnt3 axis mir-342-5p agomir group oxidative stress-induced injury mir-342-5p inhibits expression inhibits monocyte/macrophage recruitment mir-342-5p antagomir concentration mir-342-5p targeted wnt3a article download pdf overexpress mir-342-5p expression mir-342-5p antagomir group lipid/necrotic core expansion oxidative stress-related cytokines mir-342-5p targeted regulation mir-342-5p targeting wnt3a mir-342-5p expression levels oe-wnt3a group relative reduce mir-342-5p expression ding cai rupture-prone atherosclerotic plaque results mir-342-5p increases β-catenin mrna expression restored α-sma expression mir-342-5p target site including anti-fibrosis mir-342-5p inhibits image pro plus6 notch downstream molecule privacy choices/manage cookies mir-342-5p agomir β-catenin protein expression lipid content = oil red wnt signaling pathway

Schema {🗺️}

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         headline:RETRACTED ARTICLE: Down-regulation of microRNA-342-5p or Up-regulation of Wnt3a Inhibits Angiogenesis and Maintains Atherosclerotic Plaque Stability in Atherosclerosis Mice
         description:Evidence has demonstrated that microRNA-342-5p (miR-342-5p) is implicated in atherosclerosis (AS), but little is known regarding its intrinsic regulatory mechanisms. Here, we aimed to explore the effect of miR-342-5p targeting Wnt3a on formation of vulnerable plaques and angiogenesis of AS. ApoE−/− mice were fed with high-fat feed for 16 w to replicate the AS vulnerable plaque model. miR-342-5p and Wnt3a expression in aortic tissues of AS were detected. The target relationship between miR-342-5p and Wnt3a was verified. Moreover, ApoE−/− mice were injected with miR-342-5p antagomir and overexpression-Wnt3a vector to test their functions in serum lipid levels, inflammatory and oxidative stress-related cytokines, aortic plaque stability and angiogenesis in plaque of AS mice. miR-342-5p expression was enhanced and Wnt3a expression was degraded in aortic tissues of AS mice and miR-342-5p directly targeted Wnt3a. Up-regulating Wnt3a or down-regulating miR-342-5p reduced blood lipid content, inflammatory and oxidative stress levels, the vulnerability of aortic tissue plaque and inhibited angiogenesis in aortic plaque of AS mice. Functional studies show that depleting miR-342-5p can stabilize aortic tissue plaque and reduce angiogenesis in plaque in AS mice via restoring Wnt3a.
         datePublished:2021-11-22T00:00:00Z
         dateModified:2023-03-20T00:00:00Z
         pageStart:1
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            Atherosclerosis
            MicroRNA-342-5p
            Wnt3a
            Vulnerable plaque
            Vulnerability index
            Microvessel density
            Nanotechnology
            Nanotechnology and Microengineering
            Nanoscale Science and Technology
            Nanochemistry
            Molecular Medicine
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      headline:RETRACTED ARTICLE: Down-regulation of microRNA-342-5p or Up-regulation of Wnt3a Inhibits Angiogenesis and Maintains Atherosclerotic Plaque Stability in Atherosclerosis Mice
      description:Evidence has demonstrated that microRNA-342-5p (miR-342-5p) is implicated in atherosclerosis (AS), but little is known regarding its intrinsic regulatory mechanisms. Here, we aimed to explore the effect of miR-342-5p targeting Wnt3a on formation of vulnerable plaques and angiogenesis of AS. ApoE−/− mice were fed with high-fat feed for 16 w to replicate the AS vulnerable plaque model. miR-342-5p and Wnt3a expression in aortic tissues of AS were detected. The target relationship between miR-342-5p and Wnt3a was verified. Moreover, ApoE−/− mice were injected with miR-342-5p antagomir and overexpression-Wnt3a vector to test their functions in serum lipid levels, inflammatory and oxidative stress-related cytokines, aortic plaque stability and angiogenesis in plaque of AS mice. miR-342-5p expression was enhanced and Wnt3a expression was degraded in aortic tissues of AS mice and miR-342-5p directly targeted Wnt3a. Up-regulating Wnt3a or down-regulating miR-342-5p reduced blood lipid content, inflammatory and oxidative stress levels, the vulnerability of aortic tissue plaque and inhibited angiogenesis in aortic plaque of AS mice. Functional studies show that depleting miR-342-5p can stabilize aortic tissue plaque and reduce angiogenesis in plaque in AS mice via restoring Wnt3a.
      datePublished:2021-11-22T00:00:00Z
      dateModified:2023-03-20T00:00:00Z
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         Atherosclerosis
         MicroRNA-342-5p
         Wnt3a
         Vulnerable plaque
         Vulnerability index
         Microvessel density
         Nanotechnology
         Nanotechnology and Microengineering
         Nanoscale Science and Technology
         Nanochemistry
         Molecular Medicine
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      name:Department of Neurology, Qinghai Provincial People’s Hospital, Xining, China
      name:Department of Cardiac Ultrasound, Qinghai Provincial People’s Hospital, Xining, China
      name:Department of Cardiac Ultrasound, Qinghai Provincial People’s Hospital, Xining, China
      name:Department of Cardiac Ultrasound, Qinghai Provincial People’s Hospital, Xining, China
      name:Department of Cardiac Ultrasound, Qinghai Provincial People’s Hospital, Xining, China
      name:Department of Neurology, Qinghai Provincial People’s Hospital, Xining, China

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