We are analyzing https://link.springer.com/article/10.1007/s11883-020-00837-9.

Title:
The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review | Current Atherosclerosis Reports
Description:
Purpose of Review In this review, we discuss the evidence supporting the effects of statins on mast cells (MCs) in atherosclerosis and their molecular mechanism of action. Recent Findings Statins or HMG-CoA reductase inhibitors are known for their lipid-lowering properties and are widely used in the prevention and treatment of cardiovascular diseases. There is growing evidence that statins have an inhibitory effect on MCs, which contributes to the pleiotropic effect of statins in various diseases. MCs are one of the crucial effectors of the immune system which play an essential role in the pathogenesis of multiple disorders. Recent studies have shown that MCs are involved in the development of atherosclerotic plaques. MCs secrete various inflammatory cytokines (IL-6, IL4, TNF-α, and IFNγ) and inflammatory mediators (histamine, tryptase, proteoglycans) after activation by various stimulants. This, in turn, will exacerbate atherosclerosis. Statins suppress the activation of MCs via IgE inhibition which leads to inhibition of inflammatory mediators and cytokines which are involved in the development and progression of atherosclerosis. Summary In keeping with this evidence presented here, MCs can be considered as one of the therapeutic targets for statins in the treatment of atherosclerosis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

article, pubmed, mast, google, scholar, cas, cells, atherosclerosis, cell, statins, statin, sahebkar, immunol, effect, therapy, central, effects, atherosclerotic, allergy, disease, human, mashhad, research, clin, tolllike, review, mcs, treatment, cardiovascular, diseases, impact, pharmacol, med, matrix, university, medical, iran, function, content, inflammatory, activation, inflammation, plasma, levels, receptors, pathway, privacy, cookies, amirhossein, role,

Topics {✒️}

hmg-coa reductase inhibitors month download article/chapter c-reactive protein concentrations apolipoprotein e-null mice multi-functional master cell plasma d-dimer levels scavenger receptor-mediated phagocytosis mast cells—good guys flow cytometry-based characterization mast cell tryptase–marker regulates ige-dependent inflammation ten cate-hoek aj protein kinase full article pdf mast cell degranulation plasminogen activator inhibitor-1 privacy choices/manage cookies releasing proinflammatory cytokines plasma adiponectin concentrations mast cell function murine mast cells leiden academic center mast cell proteases mast cell disorders mast cell mediators carotid artery atherosclerosis expert opin pharmacother animal subjects performed simental-mendía le mast cell activation mouse mast cells vallejo-vaz aj potential therapeutic agents pharmaceutical technology institute article kouhpeikar key player cytokine related subjects arch med sci cytokine-dependent growth myd88-dependent pathway nf-κb p65 inhibiting mevalonate pathway smooth muscle cells human mast cells european economic area 3-hydroxy-3-methylglutaryl-coenzyme ccl2/ccr2 axis acta universitatis upsaliensis placebo-controlled cross curr opin cardiol

Questions {❓}

Is Interleukin-38 a key player cytokine in atherosclerosis immune gene therapy?
Mast cells—good guys with a bad image?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review
         description:In this review, we discuss the evidence supporting the effects of statins on mast cells (MCs) in atherosclerosis and their molecular mechanism of action. Statins or HMG-CoA reductase inhibitors are known for their lipid-lowering properties and are widely used in the prevention and treatment of cardiovascular diseases. There is growing evidence that statins have an inhibitory effect on MCs, which contributes to the pleiotropic effect of statins in various diseases. MCs are one of the crucial effectors of the immune system which play an essential role in the pathogenesis of multiple disorders. Recent studies have shown that MCs are involved in the development of atherosclerotic plaques. MCs secrete various inflammatory cytokines (IL-6, IL4, TNF-α, and IFNγ) and inflammatory mediators (histamine, tryptase, proteoglycans) after activation by various stimulants. This, in turn, will exacerbate atherosclerosis. Statins suppress the activation of MCs via IgE inhibition which leads to inhibition of inflammatory mediators and cytokines which are involved in the development and progression of atherosclerosis. In keeping with this evidence presented here, MCs can be considered as one of the therapeutic targets for statins in the treatment of atherosclerosis.
         datePublished:2020-05-26T00:00:00Z
         dateModified:2020-05-26T00:00:00Z
         pageStart:1
         pageEnd:8
         sameAs:https://doi.org/10.1007/s11883-020-00837-9
         keywords:
            Mast cells
            Statin
            Atherosclerosis
            Inflammation
            Angiology
            Cardiology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11883-020-00837-9/MediaObjects/11883_2020_837_Fig1_HTML.png
         isPartOf:
            name:Current Atherosclerosis Reports
            issn:
               1534-6242
               1523-3804
            volumeNumber:22
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Hamideh Kouhpeikar
               affiliation:
                     name:Birjand University of Medical Science
                     address:
                        name:Department of hematology and blood bank, Tabas school of nursing, Birjand University of Medical Science, Birjand, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zahra Delbari
               affiliation:
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thozhukat Sathyapalan
               affiliation:
                     name:University of Hull
                     address:
                        name:Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Luis E. Simental-Mendía
               affiliation:
                     name:Biomedical Research Unit, Mexican Social Security Institute
                     address:
                        name:Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tannaz Jamialahmadi
               affiliation:
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Amirhossein Sahebkar
               affiliation:
                     name:Halal Research Center of IRI, FDA
                     address:
                        name:Halal Research Center of IRI, FDA, Tehran, Iran
                        type:PostalAddress
                     type:Organization
                     name:Mashhad University of Medical Sciences
                     address:
                        name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
                     name:School of Pharmacy, Mashhad University of Medical Sciences
                     address:
                        name:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review
      description:In this review, we discuss the evidence supporting the effects of statins on mast cells (MCs) in atherosclerosis and their molecular mechanism of action. Statins or HMG-CoA reductase inhibitors are known for their lipid-lowering properties and are widely used in the prevention and treatment of cardiovascular diseases. There is growing evidence that statins have an inhibitory effect on MCs, which contributes to the pleiotropic effect of statins in various diseases. MCs are one of the crucial effectors of the immune system which play an essential role in the pathogenesis of multiple disorders. Recent studies have shown that MCs are involved in the development of atherosclerotic plaques. MCs secrete various inflammatory cytokines (IL-6, IL4, TNF-α, and IFNγ) and inflammatory mediators (histamine, tryptase, proteoglycans) after activation by various stimulants. This, in turn, will exacerbate atherosclerosis. Statins suppress the activation of MCs via IgE inhibition which leads to inhibition of inflammatory mediators and cytokines which are involved in the development and progression of atherosclerosis. In keeping with this evidence presented here, MCs can be considered as one of the therapeutic targets for statins in the treatment of atherosclerosis.
      datePublished:2020-05-26T00:00:00Z
      dateModified:2020-05-26T00:00:00Z
      pageStart:1
      pageEnd:8
      sameAs:https://doi.org/10.1007/s11883-020-00837-9
      keywords:
         Mast cells
         Statin
         Atherosclerosis
         Inflammation
         Angiology
         Cardiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11883-020-00837-9/MediaObjects/11883_2020_837_Fig1_HTML.png
      isPartOf:
         name:Current Atherosclerosis Reports
         issn:
            1534-6242
            1523-3804
         volumeNumber:22
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Hamideh Kouhpeikar
            affiliation:
                  name:Birjand University of Medical Science
                  address:
                     name:Department of hematology and blood bank, Tabas school of nursing, Birjand University of Medical Science, Birjand, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zahra Delbari
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thozhukat Sathyapalan
            affiliation:
                  name:University of Hull
                  address:
                     name:Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Luis E. Simental-Mendía
            affiliation:
                  name:Biomedical Research Unit, Mexican Social Security Institute
                  address:
                     name:Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tannaz Jamialahmadi
            affiliation:
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Amirhossein Sahebkar
            affiliation:
                  name:Halal Research Center of IRI, FDA
                  address:
                     name:Halal Research Center of IRI, FDA, Tehran, Iran
                     type:PostalAddress
                  type:Organization
                  name:Mashhad University of Medical Sciences
                  address:
                     name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
                  name:School of Pharmacy, Mashhad University of Medical Sciences
                  address:
                     name:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Current Atherosclerosis Reports
      issn:
         1534-6242
         1523-3804
      volumeNumber:22
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Birjand University of Medical Science
      address:
         name:Department of hematology and blood bank, Tabas school of nursing, Birjand University of Medical Science, Birjand, Iran
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:University of Hull
      address:
         name:Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
         type:PostalAddress
      name:Biomedical Research Unit, Mexican Social Security Institute
      address:
         name:Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:Halal Research Center of IRI, FDA
      address:
         name:Halal Research Center of IRI, FDA, Tehran, Iran
         type:PostalAddress
      name:Mashhad University of Medical Sciences
      address:
         name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
      name:School of Pharmacy, Mashhad University of Medical Sciences
      address:
         name:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Hamideh Kouhpeikar
      affiliation:
            name:Birjand University of Medical Science
            address:
               name:Department of hematology and blood bank, Tabas school of nursing, Birjand University of Medical Science, Birjand, Iran
               type:PostalAddress
            type:Organization
      name:Zahra Delbari
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      name:Thozhukat Sathyapalan
      affiliation:
            name:University of Hull
            address:
               name:Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
               type:PostalAddress
            type:Organization
      name:Luis E. Simental-Mendía
      affiliation:
            name:Biomedical Research Unit, Mexican Social Security Institute
            address:
               name:Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
               type:PostalAddress
            type:Organization
      name:Tannaz Jamialahmadi
      affiliation:
            name:Mashhad University of Medical Sciences
            address:
               name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
            name:Mashhad University of Medical Sciences
            address:
               name:Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      name:Amirhossein Sahebkar
      affiliation:
            name:Halal Research Center of IRI, FDA
            address:
               name:Halal Research Center of IRI, FDA, Tehran, Iran
               type:PostalAddress
            type:Organization
            name:Mashhad University of Medical Sciences
            address:
               name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
            name:School of Pharmacy, Mashhad University of Medical Sciences
            address:
               name:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of hematology and blood bank, Tabas school of nursing, Birjand University of Medical Science, Birjand, Iran
      name:Inflammation and Inflammatory Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK
      name:Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico
      name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Halal Research Center of IRI, FDA, Tehran, Iran
      name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
      name:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(167)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.21s.

LINK . SPRINGER . COM {}