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Keywords {🔍}

pubmed, google, scholar, cas, atherosclerosis, statins, nlrp, tlr, cells, effects, inflammasome, activation, expression, ilβ, receptor, effect, inflammation, patients, inflammatory, levels, central, atorvastatin, role, signaling, cell, atherosclerotic, shown, studies, nfĸb, tlrs, statin, disease, protein, tolllike, pathway, cholesterol, coronary, study, immune, receptors, oxldl, rosuvastatin, endothelial, leads, mice, antiinflammatory, vascular, caspase, cardiovascular, inhibition,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer suppress tlr4/myd88/nf-ĸb signaling suppressing tlr4/myd88/nf-ĸb pathway tlr4/myd88/nf-ĸb signaling pathway 5 mg/day versus 10 mg/day tlr4/myd88/nf-κb signaling 3-hydroxy-3-methylglutaryl-coa reductase tlr4/myd88/nf-ĸb pathway [137] lps-induced nf-ĸb activation hmg-coa reductase inhibitors 3-hydroxy-3-methyl-glutaryl-coenzyme large-scale randomized study bacteria-derived nucleic acids tumor necrosis factor-α nf-kβ transcription factor abolishing tgf-β signaling hmg-coa reductase inhibitor native low-density lipoprotein lipopolysaccharide–induced cytokine production large-species animal model hyperglycemia-induced endothelial dysfunction statin-induced insulin resistance myd88-deficient mice exhibit tight junction–zonula occludens-1 nf-ĸb transcription factor recombinant mouse tgf-β1 suppress nf-ĸb activity apolipoprotein e-deficient mice oxidized low-density lipoprotein affecting p65 nf-ĸb lps-treated animal models lox1-/nf-ĸb pathway mitogen-activated protein kinases renin–angiotensin system blockade stabilizing nf-ĸb inhibitors multiple host-derived molecules called pattern-recognition receptors activates nf-ĸb pathway decreases nf-ĸb activity lps-induced cytokine production nf-κb-dependent induction mitogen-activated protein kinase randomised placebo-controlled trials zeinab deris zayeri monocyte tlr-signaling network major histocompatibility complex-ii c-reactive protein levels pma-stimulated thp-1 monocytes leucine-rich extracellular region suppressed nf-ĸb activity

Questions {❓}

• Abais JM, Xia M, Zhang Y, Boini KM, Li P-L (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
• Andreakos E, Foxwell B, Feldmann M (2004) Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
• Arboix A, García-Eroles L, Oliveres M, Targa C, Balcells M, Massons J (2010) Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia?
• Bielinska A, Gluszko P (2007) Statins-are they potentially useful in rheumatology?
• Henriksbo BD, Schertzer JD (2015) Is immunity a mechanism contributing to statin-induced diabetes?
• Nelson CP, Erridge C (2019) Are toll-like receptors potential drug targets for atherosclerosis?
• Ridker PM (2013) Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
• Sahebkar A, Watts GF (2013) New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?
• Schönbeck U, Libby P (2004) Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
• Yuan C, Zhou L, Cheng J, Zhang J, Teng Y, Huang M et al (2012) Statins as potential therapeutic drug for asthma?

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      name:Department of Immunology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Immunology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Immunology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Department of Immunology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
      name:Mashhad University of Medical Science, Mashhad, Iran
      name:Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland
      name:Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
      name:Medical Research Centre, Sultan Qaboos University, Muscat, Oman
      name:Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
      name:Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, USA
      name:Halal Research Center of IRI, FDA, Tehran, Iran
      name:Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
      name:Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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