We are analyzing https://link.springer.com/article/10.1007/s00228-021-03149-2.

Title:
A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9 | European Journal of Clinical Pharmacology
Description:
Purpose AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This study aimed to investigate safety, tolerability, antibody development, and reduction of low-density lipoprotein cholesterol (LDLc) following four subcutaneous immunizations. Methods This phase I, single-blind, randomized, placebo-controlled study was conducted in a total of 72 healthy subjects with a mean fasting LDLc level at baseline of 117.1 mg/dL (range 77–196 mg/dL). Each cohort enrolled 24 subjects to receive three priming immunizations at weeks 0, 4, and 8 and to receive a single booster immunization at week 60 of either AT04A, AT06A, or placebo. In addition to safety (primary objective), the antigenic peptide- and PCSK9-specific antibody response and the impact on LDLc were evaluated over a period of 90 weeks. Results The most common systemic treatment-related adverse events (AEs) reported were fatigue, headache, and myalgia in 75% of subjects in the AT06A group and 58% and 46% of subjects in the placebo and AT04A groups, respectively. Injection site reactions (ISR) representing 63% of all treatment-emergent adverse events (TEAEs), were transient and mostly of mild or moderate intensity and rarely severe (3%). Both active treatments triggered a robust, long-lasting antibody response towards the antigenic peptides used for immunization that optimally cross-reacted with the target epitope on PCSK9. In the AT04A group, a reduction in serum LDLc was observed with a mean peak reduction of 11.2% and 13.3% from baseline compared to placebo at week 20 and 70 respectively, and over the whole study period, the mean LDLc reduction for the AT04A group vs. placebo was −7.2% (95% CI [−10.4 to −3.9], P < 0.0001). In this group, PCSK9 target epitope titers above 50 were associated with clinically relevant LDLc reductions with an individual maximal decrease of 39%. Conclusions Although both AT04A and AT06 were safe and immunogenic, only AT04A demonstrated significant LDLc-lowering activity, justifying further development. Trial registration EudraCT: 2015-001719-11. ClinicalTrials.gov Identifier: NCT02508896.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

study, ata, pcsk, treatment, ldlc, subjects, article, week, antibody, safety, immunization, pubmed, clinical, google, scholar, group, fig, weeks, response, baseline, placebo, levels, immune, cholesterol, booster, titers, groups, target, cas, analysis, data, antibodies, active, vienna, immunizations, epitope, serum, time, protein, phase, significant, performed, lipid, reduction, medical, full, total, systemic, peptides, cardiovascular,

Topics {✒️}

low single-digit µg/ml low-density lipoprotein cholesterol entire amyloid-β peptide nonparametric kruskal–wallis test contained t-cell epitopes long-lasting antibody response pcsk9-target-epitope-specific pcsk9-mimicking sequences differ assaying pre-immune sera article download pdf pcsk9-specific antibody response patient-friendly therapeutic schedules half-max titer increased immunotherapeutics targeting pcsk9 long-lasting immune response treatment-emergent adverse events periodic physical examinations pcsk9-targeting candidates open access publication indicating strong cross-reactivity high-density lipoprotein required short-term medication long-term ldlc management evelyn berger-sieczkowski entered clinical trials specific active immunotherapy fasting triglycerides ≤ 400 mg/dl specific treatment-induced effects fixed block size early clinical trials privacy choices/manage cookies free pcsk9 concentrations placebo-immunized subjects exhibited open-label study sample size calculation amino acid substitutions full access detect free pcsk9 long-term evaluation european economic area serum ldl cholesterol pcsk9 target epitope high cardiovascular risk long-lasting immunity pcsk9-specific memory full analysis set elimination half-life target protein pcsk9 serum antibody concentration total cholesterol concentrations

Questions {❓}

PCSK9 inhibition: the dawn of a new age in cholesterol lowering?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9
         description:AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This study aimed to investigate safety, tolerability, antibody development, and reduction of low-density lipoprotein cholesterol (LDLc) following four subcutaneous immunizations. This phase I, single-blind, randomized, placebo-controlled study was conducted in a total of 72 healthy subjects with a mean fasting LDLc level at baseline of 117.1 mg/dL (range 77–196 mg/dL). Each cohort enrolled 24 subjects to receive three priming immunizations at weeks 0, 4, and 8 and to receive a single booster immunization at week 60 of either AT04A, AT06A, or placebo. In addition to safety (primary objective), the antigenic peptide- and PCSK9-specific antibody response and the impact on LDLc were evaluated over a period of 90 weeks. The most common systemic treatment-related adverse events (AEs) reported were fatigue, headache, and myalgia in 75% of subjects in the AT06A group and 58% and 46% of subjects in the placebo and AT04A groups, respectively. Injection site reactions (ISR) representing 63% of all treatment-emergent adverse events (TEAEs), were transient and mostly of mild or moderate intensity and rarely severe (3%). Both active treatments triggered a robust, long-lasting antibody response towards the antigenic peptides used for immunization that optimally cross-reacted with the target epitope on PCSK9. In the AT04A group, a reduction in serum LDLc was observed with a mean peak reduction of 11.2% and 13.3% from baseline compared to placebo at week 20 and 70 respectively, and over the whole study period, the mean LDLc reduction for the AT04A group vs. placebo was −7.2% (95% CI [−10.4 to −3.9], P < 0.0001). In this group, PCSK9 target epitope titers above 50 were associated with clinically relevant LDLc reductions with an individual maximal decrease of 39%. Although both AT04A and AT06 were safe and immunogenic, only AT04A demonstrated significant LDLc-lowering activity, justifying further development. EudraCT: 2015-001719-11. ClinicalTrials.gov Identifier: NCT02508896.
         datePublished:2021-05-10T00:00:00Z
         dateModified:2021-05-10T00:00:00Z
         pageStart:1473
         pageEnd:1484
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s00228-021-03149-2
         keywords:
            Hypercholesterolemia
            PCSK9
            Active immunotherapy
            In vivo antibody development
            LDLc reduction
            First-in-human study
            Pharmacology/Toxicology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig4_HTML.png
         isPartOf:
            name:European Journal of Clinical Pharmacology
            issn:
               1432-1041
               0031-6970
            volumeNumber:77
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Markus Zeitlinger
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Martin Bauer
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Roman Reindl-Schwaighofer
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert M. Stoekenbroek
               affiliation:
                     name:University of Amsterdam
                     address:
                        name:Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gilles Lambert
               affiliation:
                     name:Université de La Réunion
                     address:
                        name:Laboratoire Inserm, UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Evelyn Berger-Sieczkowski
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Neurology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Heimo Lagler
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zoe Oesterreicher
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Beatrix Wulkersdorfer
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Petra Lührs
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gergana Galabova
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
                     name:Origenis GmbH
                     address:
                        name:Origenis GmbH, Martinsried, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Carsten Schwenke
               affiliation:
                     name:SCO:SSiS
                     address:
                        name:SCO:SSiS, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert M. Mader
               affiliation:
                     name:Medical University of Vienna
                     address:
                        name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rossella Medori
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christine Landlinger
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alexandra Kutzelnigg
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Günther Staffler
               url:http://orcid.org/0000-0003-0025-5081
               affiliation:
                     name:AFFiRiS AG
                     address:
                        name:AFFiRiS AG, Vienna, Austria
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9
      description:AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This study aimed to investigate safety, tolerability, antibody development, and reduction of low-density lipoprotein cholesterol (LDLc) following four subcutaneous immunizations. This phase I, single-blind, randomized, placebo-controlled study was conducted in a total of 72 healthy subjects with a mean fasting LDLc level at baseline of 117.1 mg/dL (range 77–196 mg/dL). Each cohort enrolled 24 subjects to receive three priming immunizations at weeks 0, 4, and 8 and to receive a single booster immunization at week 60 of either AT04A, AT06A, or placebo. In addition to safety (primary objective), the antigenic peptide- and PCSK9-specific antibody response and the impact on LDLc were evaluated over a period of 90 weeks. The most common systemic treatment-related adverse events (AEs) reported were fatigue, headache, and myalgia in 75% of subjects in the AT06A group and 58% and 46% of subjects in the placebo and AT04A groups, respectively. Injection site reactions (ISR) representing 63% of all treatment-emergent adverse events (TEAEs), were transient and mostly of mild or moderate intensity and rarely severe (3%). Both active treatments triggered a robust, long-lasting antibody response towards the antigenic peptides used for immunization that optimally cross-reacted with the target epitope on PCSK9. In the AT04A group, a reduction in serum LDLc was observed with a mean peak reduction of 11.2% and 13.3% from baseline compared to placebo at week 20 and 70 respectively, and over the whole study period, the mean LDLc reduction for the AT04A group vs. placebo was −7.2% (95% CI [−10.4 to −3.9], P < 0.0001). In this group, PCSK9 target epitope titers above 50 were associated with clinically relevant LDLc reductions with an individual maximal decrease of 39%. Although both AT04A and AT06 were safe and immunogenic, only AT04A demonstrated significant LDLc-lowering activity, justifying further development. EudraCT: 2015-001719-11. ClinicalTrials.gov Identifier: NCT02508896.
      datePublished:2021-05-10T00:00:00Z
      dateModified:2021-05-10T00:00:00Z
      pageStart:1473
      pageEnd:1484
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00228-021-03149-2
      keywords:
         Hypercholesterolemia
         PCSK9
         Active immunotherapy
         In vivo antibody development
         LDLc reduction
         First-in-human study
         Pharmacology/Toxicology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00228-021-03149-2/MediaObjects/228_2021_3149_Fig4_HTML.png
      isPartOf:
         name:European Journal of Clinical Pharmacology
         issn:
            1432-1041
            0031-6970
         volumeNumber:77
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Markus Zeitlinger
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martin Bauer
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roman Reindl-Schwaighofer
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert M. Stoekenbroek
            affiliation:
                  name:University of Amsterdam
                  address:
                     name:Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gilles Lambert
            affiliation:
                  name:Université de La Réunion
                  address:
                     name:Laboratoire Inserm, UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Evelyn Berger-Sieczkowski
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Neurology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heimo Lagler
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zoe Oesterreicher
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Beatrix Wulkersdorfer
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Petra Lührs
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gergana Galabova
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
                  name:Origenis GmbH
                  address:
                     name:Origenis GmbH, Martinsried, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Carsten Schwenke
            affiliation:
                  name:SCO:SSiS
                  address:
                     name:SCO:SSiS, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert M. Mader
            affiliation:
                  name:Medical University of Vienna
                  address:
                     name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rossella Medori
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christine Landlinger
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alexandra Kutzelnigg
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Günther Staffler
            url:http://orcid.org/0000-0003-0025-5081
            affiliation:
                  name:AFFiRiS AG
                  address:
                     name:AFFiRiS AG, Vienna, Austria
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:European Journal of Clinical Pharmacology
      issn:
         1432-1041
         0031-6970
      volumeNumber:77
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical University of Vienna
      address:
         name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
         type:PostalAddress
      name:Université de La Réunion
      address:
         name:Laboratoire Inserm, UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Neurology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
      name:Origenis GmbH
      address:
         name:Origenis GmbH, Martinsried, Germany
         type:PostalAddress
      name:SCO:SSiS
      address:
         name:SCO:SSiS, Berlin, Germany
         type:PostalAddress
      name:Medical University of Vienna
      address:
         name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
      name:AFFiRiS AG
      address:
         name:AFFiRiS AG, Vienna, Austria
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Markus Zeitlinger
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Martin Bauer
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Roman Reindl-Schwaighofer
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Robert M. Stoekenbroek
      affiliation:
            name:University of Amsterdam
            address:
               name:Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
               type:PostalAddress
            type:Organization
      name:Gilles Lambert
      affiliation:
            name:Université de La Réunion
            address:
               name:Laboratoire Inserm, UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France
               type:PostalAddress
            type:Organization
      name:Evelyn Berger-Sieczkowski
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Neurology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Heimo Lagler
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Zoe Oesterreicher
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Beatrix Wulkersdorfer
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Petra Lührs
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Gergana Galabova
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
            name:Origenis GmbH
            address:
               name:Origenis GmbH, Martinsried, Germany
               type:PostalAddress
            type:Organization
      name:Carsten Schwenke
      affiliation:
            name:SCO:SSiS
            address:
               name:SCO:SSiS, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Robert M. Mader
      affiliation:
            name:Medical University of Vienna
            address:
               name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Rossella Medori
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Christine Landlinger
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Alexandra Kutzelnigg
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
      name:Günther Staffler
      url:http://orcid.org/0000-0003-0025-5081
      affiliation:
            name:AFFiRiS AG
            address:
               name:AFFiRiS AG, Vienna, Austria
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
      name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
      name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
      name:Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
      name:Laboratoire Inserm, UMR 1188 DéTROI, Université de La Réunion, Sainte Clotilde, France
      name:Department of Neurology, Medical University of Vienna, Vienna, Austria
      name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
      name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
      name:Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria
      name:Origenis GmbH, Martinsried, Germany
      name:SCO:SSiS, Berlin, Germany
      name:Department of Medicine I, Medical University of Vienna, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria
      name:AFFiRiS AG, Vienna, Austria

External Links {🔗}(144)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.16s.

LINK . SPRINGER . COM {}