
NCBI . NLM . NIH . GOV {
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Title[redir]:
Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration - PMC
Description:
Endothelial dysfunction is widely implicated in cardiovascular pathological changes and development of vascular disease. In view of the fact that the spontaneous endothelial cell (EC) regeneration is a slow and insufficient process, it is of great ...
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Keywords {🔍}
cells, endothelial, doi, cell, smcs, vascular, reprogramming, fig, pubmed, differentiation, prsmcs, google, scholar, expression, analysis, ecs, smccdecs, human, hes, markers, factors, progenitor, smc, jag, lineage, pmc, supplementary, control, positive, article, conversion, showed, days, free, graft, induction, compared, performed, smooth, notch, stem, level, vivo, results, population, flow, data, muscle, fibroblasts, protocol,
Topics {✒️}
basic helix-loop-helix family cd31/kdr/c-kit/pdgfrα positivity cb17-prkdc scid/ncrcrl mice smc-cd34-ecs significantly improved fluorescently labelled ac-ldl smc-cd34-ecs injection group smc-cd34-ecs formed capillary smc-cd34-ecs group compared smc-cd34-ecs treated group smc-cd34-ec expressing cd31 real-time pcr showed human origin smc-cd34-ecs peri-aortic connective tissue functional vascular-resembling conduit labelling smc-cd34-ecs 50 mg/kg body weight real-time pcr revealed real-time pcr result tumour necrosis factor-alpha mir-21/akt/beta-catenin gene-encoding orf region pmc beta search evaluate pro-angiogenic therapies smc-converted ecs exhibited specific fluorochrome-conjugated antibodies real-time pcr analysis smc markers α-sma smc-converted ecs showed tissue-engineered vascular graft genome-wide analyses showed ips-generating transcription factors smc marker α-sma smc-cd34-ecs showed smc-cd34-ecs surrounded short hairpin e-cadherin smc-cd34-ecs revealed real-time pcr experiments time-dependently downregulated accompanied smc-derived ecs led recombinant jagged1-fc chimera bradford dye-binding method rna-seq analysis revealed smc-cd34-ecs compared mesenchymal markers α-sma blood flow recovery heterogeneous pr-smc population cell-cell adhesion markers tissue-engineering vascular grafts luciferase assay showed cd34-positive stem cells
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