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We are analyzing https://link.springer.com/article/10.1007/s10528-021-10041-2.

Title:
Association of eNOS and MCP-1 Genetic Variants with Type 2 Diabetes and Diabetic Nephropathy Susceptibility: A Case–Control and Meta-Analysis Study | Biochemical Genetics
Description:
Type 2 diabetes (T2D) and its secondary complications result from the complex interplay of genetic and environmental factors. To understand the role of these factors on disease susceptibility, the present study was conducted to assess the association of eNOS and MCP-1 variants with T2D and diabetic nephropathy (DN) in two ethnically and geographically different cohorts from North India. A total of 1313 subjects from two cohorts were genotyped for eNOS (rs2070744, rs869109213 and rs1799983) and MCP-1 (rs1024611 and rs3917887) variants. Cohort-I (Punjab) comprised 461 T2D cases (204 T2D with DN and 257 T2D without DN) and 315 healthy controls. Cohort-II (Jammu and Kashmir) included 337 T2D (150 T2D with DN and 187 T2D without DN) and 200 controls. Allele, genotype and haplotype frequencies were compared among the studied participants, and phenotype–genotype interactions were determined. Meta-analysis was performed to investigate the association between the selected variants and disease susceptibility. All three eNOS variants were associated with 1.5–4.0-fold risk of DN in both cohorts. MCP-1 rs1024611 conferred twofold risk towards DN progression in cohort-II, while rs3917887 provided twofold risk for both T2D and DN in both cohorts. eNOS and MCP-1 haplotypes conferred risk for T2D and DN susceptibility. Phenotype–genotype interactions showed significant associations between the studied variants and anthropometric and biochemical parameters. In meta-analysis, all eNOS variants conferred risk towards DN progression, whereas no significant association was observed for MCP-1 rs1024611. We show evidences for an association of eNOS and MCP-1 variants with T2D and DN susceptibility.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
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  • Business & Finance

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't figure out the monetization strategy.

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Keywords {🔍}

pubmed, google, scholar, diabetes, cas, diabetic, type, nephropathy, association, gene, polymorphism, endothelial, central, article, mcp, nitric, oxide, synthase, enos, disease, risk, renal, variants, patients, polymorphisms, mellitus, study, susceptibility, res, genet, kidney, monocyte, protein, analysis, genetic, clin, chemoattractant, med, metaanalysis, int, complications, biochem, content, raina, india, progression, access, mol, care, chronic,

Topics {✒️}

endothelial nitric-oxide synthase month download article/chapter cross-sectional population-based study north-west indian population surinder kumar bali end-stage renal disease late phosphorylation-dependent activation amplification-refractory mutation system tree-structured survival analysis phenotype–genotype interactions adult onset polymyositis/dermatomyositis full article pdf diabetic kidney failure progressive renal injury national research committee single nucleotide polymorphism influences mcp-1 expression american diabetes association tgfβ1 gene polymorphisms privacy choices/manage cookies oliveira-paula gh large population samples bueno júnior cr human nucleated cells enos gene polymorphisms chronic renal insufficiency nitric oxide nitric oxide 13 diabetes-related complications cross-sectional study replication-based analysis dr mohit nagpal monocyte chemoattractant protein-1 ecnos gene polymorphism renal tubular damage related subjects enpp1 gene variants chronic kidney disease chronic myeloproliferative disorders blood uric acid article raina arterial wall stiffness identifying genetic susceptibilities tanus-santos je published maps diabetic kidney disease inflammatory cytokine genes incident diabetes mellitus genetic association studies severe diabetic retinopathy

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Association of eNOS and MCP-1 Genetic Variants with Type 2 Diabetes and Diabetic Nephropathy Susceptibility: A Case–Control and Meta-Analysis Study
         description:Type 2 diabetes (T2D) and its secondary complications result from the complex interplay of genetic and environmental factors. To understand the role of these factors on disease susceptibility, the present study was conducted to assess the association of eNOS and MCP-1 variants with T2D and diabetic nephropathy (DN) in two ethnically and geographically different cohorts from North India. A total of 1313 subjects from two cohorts were genotyped for eNOS (rs2070744, rs869109213 and rs1799983) and MCP-1 (rs1024611 and rs3917887) variants. Cohort-I (Punjab) comprised 461 T2D cases (204 T2D with DN and 257 T2D without DN) and 315 healthy controls. Cohort-II (Jammu and Kashmir) included 337 T2D (150 T2D with DN and 187 T2D without DN) and 200 controls. Allele, genotype and haplotype frequencies were compared among the studied participants, and phenotype–genotype interactions were determined. Meta-analysis was performed to investigate the association between the selected variants and disease susceptibility. All three eNOS variants were associated with 1.5–4.0-fold risk of DN in both cohorts. MCP-1 rs1024611 conferred twofold risk towards DN progression in cohort-II, while rs3917887 provided twofold risk for both T2D and DN in both cohorts. eNOS and MCP-1 haplotypes conferred risk for T2D and DN susceptibility. Phenotype–genotype interactions showed significant associations between the studied variants and anthropometric and biochemical parameters. In meta-analysis, all eNOS variants conferred risk towards DN progression, whereas no significant association was observed for MCP-1 rs1024611. We show evidences for an association of eNOS and MCP-1 variants with T2D and DN susceptibility.
         datePublished:2021-02-20T00:00:00Z
         dateModified:2021-02-20T00:00:00Z
         pageStart:966
         pageEnd:996
         sameAs:https://doi.org/10.1007/s10528-021-10041-2
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            Genetic variant
            Type 2 diabetes
            Diabetic nephropathy
            eNOS
            MCP-1
            Human Genetics
            Biochemistry
            general
            Zoology
            Medical Microbiology
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            volumeNumber:59
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      headline:Association of eNOS and MCP-1 Genetic Variants with Type 2 Diabetes and Diabetic Nephropathy Susceptibility: A Case–Control and Meta-Analysis Study
      description:Type 2 diabetes (T2D) and its secondary complications result from the complex interplay of genetic and environmental factors. To understand the role of these factors on disease susceptibility, the present study was conducted to assess the association of eNOS and MCP-1 variants with T2D and diabetic nephropathy (DN) in two ethnically and geographically different cohorts from North India. A total of 1313 subjects from two cohorts were genotyped for eNOS (rs2070744, rs869109213 and rs1799983) and MCP-1 (rs1024611 and rs3917887) variants. Cohort-I (Punjab) comprised 461 T2D cases (204 T2D with DN and 257 T2D without DN) and 315 healthy controls. Cohort-II (Jammu and Kashmir) included 337 T2D (150 T2D with DN and 187 T2D without DN) and 200 controls. Allele, genotype and haplotype frequencies were compared among the studied participants, and phenotype–genotype interactions were determined. Meta-analysis was performed to investigate the association between the selected variants and disease susceptibility. All three eNOS variants were associated with 1.5–4.0-fold risk of DN in both cohorts. MCP-1 rs1024611 conferred twofold risk towards DN progression in cohort-II, while rs3917887 provided twofold risk for both T2D and DN in both cohorts. eNOS and MCP-1 haplotypes conferred risk for T2D and DN susceptibility. Phenotype–genotype interactions showed significant associations between the studied variants and anthropometric and biochemical parameters. In meta-analysis, all eNOS variants conferred risk towards DN progression, whereas no significant association was observed for MCP-1 rs1024611. We show evidences for an association of eNOS and MCP-1 variants with T2D and DN susceptibility.
      datePublished:2021-02-20T00:00:00Z
      dateModified:2021-02-20T00:00:00Z
      pageStart:966
      pageEnd:996
      sameAs:https://doi.org/10.1007/s10528-021-10041-2
      keywords:
         Genetic variant
         Type 2 diabetes
         Diabetic nephropathy
         eNOS
         MCP-1
         Human Genetics
         Biochemistry
         general
         Zoology
         Medical Microbiology
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                     name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
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            name:Surinder Kumar Bali
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                  address:
                     name:Department of General Medicine, Government Medical College, Jammu, India
                     type:PostalAddress
                  type:Organization
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            name:Virinder Singh
            affiliation:
                  name:Dr Virinder Singh Kidney Clinic and Dialysis Centre
                  address:
                     name:Dr Virinder Singh Kidney Clinic and Dialysis Centre, Amritsar, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:AJS Bhanwer
            affiliation:
                  name:Guru Nanak Dev University
                  address:
                     name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
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         name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
         type:PostalAddress
      name:London School of Hygiene and Tropical Medicine
      address:
         name:Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
         type:PostalAddress
      name:Guru Nanak Dev University
      address:
         name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
         type:PostalAddress
      name:Government Medical College
      address:
         name:Department of General Medicine, Government Medical College, Jammu, India
         type:PostalAddress
      name:Dr Virinder Singh Kidney Clinic and Dialysis Centre
      address:
         name:Dr Virinder Singh Kidney Clinic and Dialysis Centre, Amritsar, India
         type:PostalAddress
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      address:
         name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
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      affiliation:
            name:Guru Nanak Dev University
            address:
               name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
               type:PostalAddress
            type:Organization
      name:Ruhi Sikka
      affiliation:
            name:Guru Nanak Dev University
            address:
               name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
               type:PostalAddress
            type:Organization
      name:Himanshu Gupta
      affiliation:
            name:London School of Hygiene and Tropical Medicine
            address:
               name:Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
               type:PostalAddress
            type:Organization
      name:Kawaljit Matharoo
      affiliation:
            name:Guru Nanak Dev University
            address:
               name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
               type:PostalAddress
            type:Organization
      name:Surinder Kumar Bali
      affiliation:
            name:Government Medical College
            address:
               name:Department of General Medicine, Government Medical College, Jammu, India
               type:PostalAddress
            type:Organization
      name:Virinder Singh
      affiliation:
            name:Dr Virinder Singh Kidney Clinic and Dialysis Centre
            address:
               name:Dr Virinder Singh Kidney Clinic and Dialysis Centre, Amritsar, India
               type:PostalAddress
            type:Organization
      name:AJS Bhanwer
      affiliation:
            name:Guru Nanak Dev University
            address:
               name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
      name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
      name:Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
      name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
      name:Department of General Medicine, Government Medical College, Jammu, India
      name:Dr Virinder Singh Kidney Clinic and Dialysis Centre, Amritsar, India
      name:Department of Human Genetics, Guru Nanak Dev University, Amritsar, India
WebPageElement:
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