
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin - PMC
Description:
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of ...
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Keywords {🔍}
alirocumab, atorvastatin, pcsk, doi, pubmed, google, scholar, cholesterol, lesion, atherosclerosis, treatment, mice, combination, levels, compared, plasma, ldlr, fig, mgkg, study, area, lesions, van, control, effects, effect, decreased, patients, aortic, data, pmc, development, protein, ldlc, group, plaque, type, weeks, article, hepatic, apoeleidencetp, increased, reduction, root, lipid, ldl, statin, free, antibody, phase,
Topics {✒️}
hematoxylin-phloxine-saffron smooth muscle cell smooth muscle cells elevated c-reactive protein dose-dependent cholesterol-lowering effects rabbit anti-goat hrp semisynthetic cholesterol-rich diet combined hmg-coa reductase horse anti-mouse hrp goat anti-mouse ldlr pmc beta search ldlr-deficient mice expressing fenofibrate increases hdl-cholesterol including t-cell abundance mouse anti-α-tubulin national cholesterol education anti-human α-actin adhesion molecule expression pmc copyright notice hps-stained atherosclerotic lesions serine protease involved dose-dependent inhibitory effect ldlr protein levels collagen-poor fibrous cap cholesterol-fed apoe3-leiden diet-induced hyperlipoproteinemia t-cell recruitment lesion-free sections plasma total cholesterol normal wild-type mice lowering ldl cholesterol reducing hepatic expression affect hepatic cholesterol hepatic cholesterol homeostasis expert dyslipidemia panel secreted pcsk9 decreases dose-dependently enhanced low plasma levels decreased plasma cholesterol fast protein lc reduced monocyte adhesion intensive lipid lowering hepatic cholesterol content ldl-bound ldlr ldlr mrna levels decreased plasma ldl increased vldl cholesterol reducing nonhdl-cholesterol western-type diet ldl receptor
Questions {❓}
- Plaque stabilization: can we turn theory into evidence?
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