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We are analyzing https://www.nature.com/articles/s12276-020-00504-8.

Title:
Glutamine reliance in cell metabolism | Experimental & Molecular Medicine
Description:
As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer. Insights into how the amino acid glutamine powers cellular metabolism could pave the way for effective therapeutic strategies for ‘starving’ tumor cells. Healthy cells can manufacture enough glutamine to sustain normal function, but cancerous growth creates heavier demand for this important molecule. Jung Min Han and colleagues at Yonsei University in Incheon, South Korea have reviewed the various cellular functions of glutamine, and discuss opportunities to cut off supply and thereby derail tumor proliferation. Glutamine serves as a building block both for amino acids and nucleic acids, and is also consumed during mitochondrial energy production. Several groups are exploring the feasibility of inactivating glutamine synthesis or halting cellular uptake of this amino acid as a means of depriving cancer cells of nutrients. A deeper understanding of glutamine’s metabolic functions should accelerate progress on this front.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

glutamine, pubmed, cancer, article, google, scholar, cas, cells, cell, metabolism, central, metabolic, mitochondrial, αkg, slca, glutamate, glutaminolysis, growth, tumor, biosynthesis, synthesis, fig, acid, cellular, idh, cycle, amino, role, asparagine, fumarate, pathway, dehydrogenase, succinate, nature, mtorc, glutaminederived, hifα, glutathione, tca, gls, enzymes, activation, production, autophagy, metab, expression, glutaminase, levels, hypoxia, addition,

Topics {✒️}

nature portfolio gpna l-γ-glutamyl-p-nitroanilide privacy policy suppressing wnt/beta-catenin pathway regional glutamine deficiency don 6-diazo-5-oxo-l-norleucine advertising k-ras-driven cancer cells185 national research foundation gfat glutamine-fructose-6-phosphate transaminase social media k-ras-driven cancer cells regulating α-kg-dependent dioxygenases converting glutamine-derived α-kg l-2hgdh l-2-hydroxyglutarate dehydrogenase reprints na+-dependent anion leak experimental data showing k-ras sensitizes cells k-ras mutant cells glutamine-derived α-kg activates jung min han nature https triple-negative breast cancer deactivates peroxide-free radicals forkhead box p3-positive oncogenic k-ras maintains k-ras-driven cells research groups kras-mutated colorectal cancer glutamine-derived r-2-hg accumulates experimental gut-origin sepsis gpt glutamic-pyruvate transaminase mapk-dependent signaling pathway α-kg-dependent dioxygenases amplify ros-dependent signaling luminal-subtype breast cancer ngamma-aryl glutamine analogues pi3kca-driven signaling activation increased chromatin o-glcnacylation nrf2-dependent antioxidant pathways fgar n2-formyl-n1 kras-driven cancer cells research sustaining endoplasmic reticulum pyruvate-derived acetyl-coa α-kg-dependent histone constitutive hif-2α stabilization75 sodium-independent transport system α-kg a-ketoglutarate

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      headline:Glutamine reliance in cell metabolism
      description:As knowledge of cell metabolism has advanced, glutamine has been considered an important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study provided a new perspective on mitochondrial glutamine metabolism, offering mechanistic insights into metabolic adaptation during tumor hypoxia, the emergence of drug resistance, and glutaminolysis-induced metabolic reprogramming and presenting metabolic strategies to target glutamine metabolism in cancer cells. In this review, we introduce the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamine metabolism to explain why cells exhibit metabolic reliance on glutamine. Additionally, we examined whether glutamine derivatives contribute to epigenetic regulation associated with tumorigenesis. In addition, in discussing glutamine transporters, we propose a metabolic target for therapeutic intervention in cancer. Insights into how the amino acid glutamine powers cellular metabolism could pave the way for effective therapeutic strategies for ‘starving’ tumor cells. Healthy cells can manufacture enough glutamine to sustain normal function, but cancerous growth creates heavier demand for this important molecule. Jung Min Han and colleagues at Yonsei University in Incheon, South Korea have reviewed the various cellular functions of glutamine, and discuss opportunities to cut off supply and thereby derail tumor proliferation. Glutamine serves as a building block both for amino acids and nucleic acids, and is also consumed during mitochondrial energy production. Several groups are exploring the feasibility of inactivating glutamine synthesis or halting cellular uptake of this amino acid as a means of depriving cancer cells of nutrients. A deeper understanding of glutamine’s metabolic functions should accelerate progress on this front.
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