We are analyzing https://link.springer.com/article/10.1007/s00018-005-5410-y.

Title:
Anaplerotic roles of pyruvate carboxylase in mammalian tissues | Cellular and Molecular Life Sciences
Description:
Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-γ, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the ‘pyruvate/malate cycle’ to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.
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Keywords {🔍}

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Topics {✒️}

glucose-induced insulin secretion peroxisome proliferator-activated receptor-γ �pyruvate/malate cycle de novo synthesis shuttle 3c month download article/chapter determine tissue-specific expression pyruvate carboxylase glyceroneogenesis lipogenesis astrocytes glutamate diabetes privacy choices/manage cookies form malate full article pdf check access instant access tricarboxylic acid cycle european economic area scope submit manuscript atp-dependent carboxylation mechanistic biological marker anaplerotic roles clinical biochemistry conditions privacy policy accepting optional cookies related subjects author correspondence pyruvate vidal-puig school pc gene pinpoint article cellular journal finder publish biochemistry life sci article log mammalian tissues privacy policy personal data anaplerotic role books a article cite article jitrapakdee optional cookies manage preferences subscription content similar content vidal-puig vidal-puig

Schema {🗺️}

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         headline:Anaplerotic roles of pyruvate carboxylase in mammalian tissues
         description:Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-γ, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the ‘pyruvate/malate cycle’ to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.
         datePublished:2006-02-28T00:00:00Z
         dateModified:2006-02-28T00:00:00Z
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            biotin carboxylase
            glucose-induced insulin secretion
            pyruvate/malate shuttle
            pyruvate/citrate shuttle
            type 2 diabetes
            lipogenesis
            glyceroneogenesis
            astrocytes
            glutamate synthesis
            Cell Biology
            Biomedicine
            general
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            Biochemistry
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      headline:Anaplerotic roles of pyruvate carboxylase in mammalian tissues
      description:Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate. PC serves an anaplerotic role for the tricarboxylic acid cycle, when intermediates are removed for different biosynthetic purposes. In liver and kidney, PC provides oxaloacetate for gluconeogenesis. In adipocytes PC is involved in de novo fatty acid synthesis and glyceroneogenesis, and is regulated by the peroxisome proliferator-activated receptor-γ, suggesting that PC is involved in the metabolic switch controlling fuel partitioning toward lipogenesis. In islets, PC is necessary for glucose-induced insulin secretion by providing oxaloacetate to form malate that participates in the ‘pyruvate/malate cycle’ to shuttle 3C or 4C between mitochondria and cytoplasm. Hyperglycemia and hyperlipidemia impair this cycle and affect glucose-stimulated insulin release. In astrocytes, PC is important for de novo synthesis of glutamate, an important excitatory neurotransmitter supplied to neurons. Transcriptional studies of the PC gene pinpoint some transcription factors that determine tissue-specific expression.
      datePublished:2006-02-28T00:00:00Z
      dateModified:2006-02-28T00:00:00Z
      pageStart:843
      pageEnd:854
      sameAs:https://doi.org/10.1007/s00018-005-5410-y
      keywords:
         Pyruvate carboxylase
         biotin carboxylase
         glucose-induced insulin secretion
         pyruvate/malate shuttle
         pyruvate/citrate shuttle
         type 2 diabetes
         lipogenesis
         glyceroneogenesis
         astrocytes
         glutamate synthesis
         Cell Biology
         Biomedicine
         general
         Life Sciences
         Biochemistry
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