
NCBI . NLM . NIH . GOV {
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Title[redir]:
Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle - PMC
Description:
In multicellular organisms, cell division is regulated by growth factors (GFs). In the absence of GFs, cells exit the cell cycle at a site in G1 referred to as the restriction point (R) and enter a state of quiescence known as G0. Additionally, ...
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Keywords {๐}
cells, cell, pubmed, cycle, eaa, doi, rapamycin, deprivation, google, scholar, figure, checkpoints, arrest, cancer, conditions, blocking, mtor, growth, sphase, metabolic, progression, block, pmc, time, levels, amino, shown, acid, phosphorylation, article, htdr, free, incorporation, point, data, gmphase, complete, treatment, response, dmem, indicating, error, nutrient, experiments, factor, obtained, cyclin, serum, protein, starting,
Topics {โ๏ธ}
g2/m-phase cell population phosphatidylinositol 3-kinase/akt-dependent pathway 1ml phosphate-buffered saline high micro-molar doses pmc beta search platelet-derived growth factor late-g1 metabolic checkpoints phase-specific cytotoxic drugs g2/m-phase โ indicating measuring dna content/cell mutant k-ras signals g2/m-phase arrest pi3k-frap/mtor pathway nutrient-mediated metabolic checkpoints autophagy marker lc3-ii nutrient-dependent metabolic checkpoints 1ยตci/ml [3h]-thymidine g2/m-phase cells 1 ยตci/ml [3h]-tdr [3h]-tdr incorporation- indicating 40ยตg/ml propidium iodide pdgf-activated phosphatidylinositol 3-kinase increased [3h]-tdr incorporation gf-dependent mid-g1 significant [3h]-tdr incorporation s-phase dna content results growth factor metabolic checkpoints late license information pmcid cell cycle checkpoints cell cycle progression cell cycle distribution tor-regulated start responds cell lines retained cell lines tested key regulatory site mutant k-ras g2/m-phase arrest sites mediated g1 cell population mid-g1 arrest phosphatidylinositol kinase homologue g1-phase cells released measuring dna content metabolic checkpoints relative nutritional checkpoints mediated amino acid sites cell division cycle remove cell aggregates protein kinase encoded
Questions {โ}
- Foster DA (2007) Regulation of mTOR by phosphatidic acid?
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