
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity - PMC
Description:
Otto Warburg
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Keywords {π}
cells, mitochondrial, growth, doi, fig, ros, cell, tumor, glycolysis, google, scholar, metabolism, proliferation, glutamine, pubmed, cancer, anchorageindependent, cybrids, required, levels, pathway, agar, soft, pmc, shrna, article, cycle, complex, results, tca, hct, Ξ΄cytochrome, oxidative, glucose, iii, generation, phosphorylation, phosphate, mice, analysis, lslkras, free, aerobic, atp, pentose, erk, presence, control, protein, colony,
Topics {βοΈ}
lsl-kras g12d mice kras-induced anchorage-independent growth oncogene-induced anchorage-independent growth lsl-krasg12d 3t3 mefs lslkrasg12d3t3 +cre/immortalized lslkrasg12d oncogenic kras-induced growth diminishes anchorage-independent growth lsl-kras g12d termed lsl-krasg12d 3t3mefs attenuate anchorage-independent growth subsequent anchorage-independent growth prevents anchorage-independent growth anchorage-independent manner suggests lox-stop-lox krasg12 kras-induced cell proliferation lsl-kras g12dfl/+ oncogenic kras-transformed cells org/lookup/suppl/doi cell permeable alpha-ketoglutarate 48-hours post-treatment suggesting pmc beta search oncogene-induced transformation depends wild-type kras allele regulating oncogene-induced tumorigenicity krasv12-p53dn cells/immortalized p53dn glucose-free media enriched myr-akt-p53dn mefs oncogenic kras induced extracellular signal-regulated kinase kras-induced growth dmk-induced colony growth supplementary materials included xenograft tumor formation lsl-krasg12d allele superoxide dismutase mimetics wild-type 143b cybrids anchorage-independent growth complex iii-generated ros anchorage-independent manner anchorage independent-manner kras-mediated tumorigenicity oncogenic kras mutation free radical production regulate cell proliferation supporting information online oncogene-induced tumorigenicity require glutamine catabolism upstream mek kinase reactive oxygen species tfam floxed mice
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