
NCBI . NLM . NIH . GOV {
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Title[redir]:
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism - PMC
Description:
Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent molecular features ...
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Keywords {🔍}
cells, cpta, lipid, doi, rcc, cell, fig, vhl, expression, ccrcc, acid, tumor, hif, fatty, pubmed, google, scholar, hifα, renal, cancer, pmc, article, deposition, metabolism, formation, droplet, oil, red, hypoxia, free, activity, tumors, quantification, performed, clear, growth, accumulation, found, staining, gene, compared, glucose, carcinoma, droplets, storage, normal, glutamine, knockdown, data, mitochondria,
Topics {✒️}
4a-diaza-s-indacene-3-dodecanoic acid oxidized low-density lipoprotein von hippel–lindau disease von-hippel lindau disease hypoxia-inducible factor-dependent gene cis-unsaturated fatty acids hypoxia-inducible scavenger receptor nih r21 ca178157-01a1 dysregulated d-dopachrome tautomerase gas chromatography-mass spectrometry er-bound enzymes leads quantitative real-time pcr median-centered intensity expression fitc-labeled secondary antibody pmc beta search kaplan–meier survival plot rate-limiting component controlling phosphatidylinositol 3-kinase-dependent mechanisms 4-difluoro-5-methyl-4-bora-3a requiring additional hypoxia-mediated hypoxia-regulated epigenetic regulators long-chain fatty acids14 oxidative stress-induced toxicity methods cell culture malonyl-coa-sensitive form sensitizes vhl-deficient cells clear-cell carcinoma hypoxia-induced-lipid storage doxycycline-inducible cell line produce cytosolic acetyl-coa author contributions glycogen-rich cytoplasmic deposits hypoxia-inducible factors involved oct-embedded tumor sections renal cell carcinoma reduces mitochondrial respiration18 vhl-deficient rcc cells parental vhl-deficient cells lipid transporter cd36 labeled fatty acid fatty acid transport promotes tumor growth glutamine-derived α-ketoglutarate cpt1a-expressing adenovirus implanted supplementary materials included tumor-specific metabolic adaptation doxycycline-inducible cpt1am expression fatty acid uptake means ± standard deviations hypoxia-inducible factor-1
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- How much profit does https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office make?
- What is the monthly revenue of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- What's the financial outcome of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- What's the total monthly financial gain of https://www.nlm.nih.gov/accessibility.html?
- How much cash flow does https://www.nlm.nih.gov/careers/careers.html have monthly?
- What is the earnings of https://www.nlm.nih.gov/?
- How much cash flow does https://www.nih.gov/ have monthly?
- What's the financial gain of https://www.hhs.gov/?
- See how much https://www.usa.gov/ makes per month
Analytics and Tracking {📊}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi