
DOI . ORG {
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Title[redir]:
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity | PNAS
Description:
Otto Warburg
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Keywords {🔍}
cells, mitochondrial, growth, fig, ros, cell, tumor, metabolism, crossref, glycolysis, google, scholar, proliferation, glutamine, cancer, anchorageindependent, cybrids, pubmed, required, levels, pathway, agar, soft, tca, shrna, generation, results, cycle, complex, hct, δcytochrome, view, oxidative, glucose, iii, phosphorylation, phosphate, mice, analysis, lslkras, articles, research, aerobic, atp, pentose, erk, presence, role, control, protein,
Topics {✒️}
lsl-kras g12d mice kras-induced anchorage-independent growth oncogene-induced anchorage-independent growth lsl-krasg12d 3t3 mefs otto warburg observed methods full methods lslkrasg12d3t3 +cre/immortalized lslkrasg12d oncogenic kras-induced growth diminishes anchorage-independent growth colon laurent peyrin-biroulet lsl-kras g12d termed lsl-krasg12d 3t3mefs attenuate anchorage-independent growth subsequent anchorage-independent growth prevents anchorage-independent growth anchorage-independent manner suggests lox-stop-lox krasg12 jan-willem van ittersum kras-induced cell proliferation lsl-kras g12dfl/+ oncogenic kras-transformed cells cell permeable alpha-ketoglutarate 48-hours post-treatment suggesting glucose-free media enriched oncogene-induced transformation depends regulating oncogene-induced tumorigenicity krasv12-p53dn cells/immortalized p53dn wild-type kras allele kras-mediated tumorigenicity proceedings myr-akt-p53dn mefs oncogenic kras induced extracellular signal-regulated kinase pnas direct submission dmk-induced colony growth kras-induced growth complex iii-generated ros xenograft tumor formation lsl-krasg12d allele superoxide dismutase mimetics wild-type 143b cybrids anchorage-independent growth sophisticated auditory–motor learning anchorage-independent manner anchorage independent-manner authors declare kras-mediated tumorigenicity oncogenic kras mutation oncogene-induced tumorigenicity citation information map kinase pathway
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