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Keywords {🔍}

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Topics {✒️}

n-methyl-n-tert-butyldimethylsilyltrifluoroacetamide condensing glucose-derived acetyl-coa org/lookup/suppl/doi pmc beta search metabolite consumption/production values dimethyl α-ketoglutarate rescued gas chromatography-mass spectrometry vhl-deficient rcc4 cells constitutive hif1α-expressing cells 4 mm [u-13c]glutamine 10 mm [u-13c]glucose oxidative nad+-dependent reactions [u-13c]-l-glutamine glucose uniformly 13c-labeled vhl tumor suppressor [u-13c]-d-glucose glutamine-derived α-ketoglutarate glutamine-derived α-ketoglutarate+5 d-2-hydroxyglutarate dehydrogenase gene growth factor-dependent regulation glutamine-deficient medium displayed glucose-derived acetyl-coa tca cycle-dependent conversion α-ketoglutarate+5 produces fumarate+4 glutamine-deficient medium supplemented glucose-deficient medium supplemented carbon molecule acetyl-coa increased idh2-dependent carboxylation α-ketoglutarate levels increased glutamine-dependent citrate production glucose-dependent citrate production glucose-dependent citrate synthesis hif1-induced metabolic reprogramming rcc4 cells expressing idh2-dependent citrate synthesis idh2-mediated reductive carboxylation oxygen-dependent proteolysis glutamine-starved sf188 cells supplementary materials included primary anaplerotic substrate publisher site pdf hypoxia-inducible factor 1 physiol cell physiol hif-1-mediated expression atp-citrate lyase pdh-generated acetyl-coa+2 transcription factor hif1 rcc4 vhl−/− cells license information pmcid tca cycle depend

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