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Keywords {🔍}

glutamine, myc, figure, doi, cells, glucose, aerobic, hypoxia, tca, cell, cycle, google, scholar, pubmed, metabolism, conditions, hypoxic, glutaminase, labeled, pmc, production, cancer, article, pyruvate, free, bptes, levels, glutamate, citrate, glutathione, lactate, tumor, proliferation, ccitrate, ros, growth, determined, consumption, isotopologue, mitochondrial, isotopologues, metabolic, fumarate, pathway, metabolites, data, dang, absence, activity, circles,

Topics {✒️}

yields 13c2/13c1-acetyl coa high-resolution ft-icr-ms 13c-labeled glutamine-derived α-ketoglutarate uniformly labeled [u-13c]-glc luciferin– luciferase-based assay luciferin–luciferase-based assay pmc beta search full-length human glutaminase ft-icr-ms determination ft-icr-ms instrumentation tumor-bearing scid mice disorganized goal-directed behavior clark-type oxygen electrode nutrient-poor tumor microenvironments rat kidney-type glutaminase glucose-independent tca cycle uniformly labeled [u-13c cell metab summary revealed bptes-induced metabolic glutamine-driven tca cycle uniformly 13c-labeled glucose glucose-dependent tca cycle glutamine-independent tumor cells cytoplasmic atp-citrate lyase produces 13c2-acetyl coa supplementary materials included reactive oxygen species tetracycline-repressible myc construct doubly 13c-labeled isotopologue 5 mg/kg bodyweight glutamine-dependent redox homeostasis cancer-related metabolic pathways model cell line [u-13c]-labeled glucose glutamine-mediated tca cycle bptes-treated mice demonstrated glucose-derived α-ketoglutarate induce mitochondrial biogenesis glutamine-derived α-ketoglutarate 13c-labeled metabolites derived myc-dependent hypoxic metabolism tumor xenograft growth license information pmcid assess glutaminase activity glucose-deprived culture conditions hypoxia inducible factor hypoxia-inducible factor 1 grant numbers 1r21ns074151-01 hypoxia-induced ros production glutamine-independent growth

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