We are analyzing https://link.springer.com/article/10.1007/s13238-021-00841-y.

Title:
Ferroptosis, radiotherapy, and combination therapeutic strategies | Protein & Cell
Description:
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
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Keywords {🔍}

ferroptosis, pubmed, google, scholar, cancer, cas, cell, cells, central, lipid, tumor, death, slca, fig, protein, peroxidation, gpx, zhang, cellular, wang, expression, biol, rtinduced, role, radiation, liu, autophagy, iron, apoptosis, studies, radiotherapy, response, chen, lei, mechanisms, induces, damage, fins, promotes, radioresistance, stress, dna, activity, including, targeting, therapy, levels, activation, system, chem,

Topics {✒️}

phorbol-12-myristate-13-acetate-induced protein 1 cystine/glutamate transporter-deficient mice therapy-resistant high-risk neuroblastoma apoptosis-inducing factor-homologous mitochondrion kras-mutant lung adenocarcinoma anti-pd-1/pd-l1 combinations camp-response-element-binding protein hif-2ɑ activates hypoxia-induced slc7a11/xct-mediated cystine uptake cystine/glutamate antiporter system h-fsp1-coq axis acts h-fsp1-coq] signaling axis spermidine/spermine n1-acetyltransferase 1 rt-induced lung injury nf-e2–related factor 2 therapy-resistant high-mesenchymal article download pdf p53-inducible apoptogenic gene p53-inducible gene downregulated radiation-induced cell death suppresses acetyl-coa carboxylase amp-activated protein kinase prevent hydroperoxide-induced ferroptosis gpx4-independent defense systems p53-mediated ferroptotic responses lysophosphatidylcholine-induced cellular injury effective lipid-soluble antioxidant unstable carbon-centered radicals robust radical-trapping antioxidant pparα-mediated lipid remodeling cystine transporter slc7a11/xct system xc-mutant mice drug-resistant cancer cells induces caspase-independent apoptosis restraining pufa-pl biosynthesis b-raf proto-oncogene de la vega slc7a11-mediated cystine uptake inhibits rt-induced ferroptosis blocking pufa-pl synthesis glutathione-independent ferroptosis suppressor p53-null leukemic cells radiotherapy-induced cell death iron-dependent cell death ferroptosis-resistant cell state family member protein p53-mediated tumour suppression rt-mediated anticancer effects inhibited ir-induced ferroptosis experimental radiation oncology

Questions {❓}

Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A (2018) How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Kang R, Tang D (2016) What is the pathobiology of inflammation to cell death?
Rao SG, Jackson JG (2016) SASP: tumor suppressor or promoter?
Wang H, Jiang H, Van De Gucht M, De Ridder M (2019a) Hypoxic radioresistance: can ROS be the key to overcome it?

Schema {🗺️}

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         description:Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
         datePublished:2021-04-23T00:00:00Z
         dateModified:2021-04-23T00:00:00Z
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            lipid peroxidation
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            SLC7A11
            radiotherapy
            immunotherapy
            radiosensitization
            combination therapy
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            Protein Science
            Cell Biology
            Stem Cells
            Human Genetics
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      headline:Ferroptosis, radiotherapy, and combination therapeutic strategies
      description:Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.
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      dateModified:2021-04-23T00:00:00Z
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         ferroptosis
         lipid peroxidation
         GPX4
         SLC7A11
         radiotherapy
         immunotherapy
         radiosensitization
         combination therapy
         Biochemistry
         general
         Protein Science
         Cell Biology
         Stem Cells
         Human Genetics
         Developmental Biology
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                  address:
                     name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
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         name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
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               type:PostalAddress
            type:Organization
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Chao Mao
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Yuelong Yan
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Li Zhuang
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
      name:Boyi Gan
      affiliation:
            name:The University of Texas MD Anderson Cancer Center
            address:
               name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
               type:PostalAddress
            type:Organization
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      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
      name:The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, USA

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