We are analyzing https://link.springer.com/article/10.1186/s13045-023-01466-w.

Title:
Small RNA modifications: regulatory molecules and potential applications | Journal of Hematology & Oncology
Description:
Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells. Small RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. Current evidence suggest that small RNAs can also have diverse modifications to their nucleotide composition that affect their stability as well as their capacity for nuclear export, and these modifications are relevant to their capacity to drive molecular signaling processes relevant to biogenesis, cell proliferation and differentiation. In this review, we highlight the molecular characteristics and cellular functions of small RNA and their modifications, as well as current techniques for their reliable detection. We also discuss how small RNA modifications may be relevant to the clinical applications for the diagnosis and treatment of human health conditions such as cancer.
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Keywords {🔍}

pubmed, article, google, scholar, rna, cas, small, rnas, central, cell, modifications, cancer, modification, methylation, biol, zhang, cells, mirna, mol, trna, nat, mettl, wang, human, mirnas, promotes, liu, protein, chen, functions, expression, res, nmethyladenosine, processing, noncoding, found, levels, maturation, lung, hen, sperm, function, yang, potential, detection, pseudouridine, reported, sequencing, nucleic, microrna,

Topics {✒️}

pten-mediated pi3k/akt/mtor pathway m6a-mediated mir-106b-5p processing mir-1246/spred2/mapk signaling pathway expression profile mir-486–5p/rap1-nf-kappa a-dependent pri-mir-365-3p processing pri-mir-34a-5p high-fat diet-induced elevation increases mir-34a-5p n-6-methyladenosine-dependent microrna maturation view demethylate pri-mir-320a-3p high-fat diet-induced sperm low mirna-181a-5p expression n6-methyladenosine-mediated downregulation accelerating pri-microrna-221-3p maturation induced cell senescence silica-induced pulmonary fibrosis rna n6-methyladenosine methyltransferase dynamic n-1-methyladenosine methylome double-stranded rna-binding protein silica-induced lung fibrosis n6-methyladenosine-dependently regulating mrna-binding factor rbm15/spenito increase pre-mir-143-3p splicing hplc-coupled mass spectrometry article download pdf unmethylated mirna-181a-5p trmt6/61a-dependent base methylation nsun2-dependent mir-125b downregulation runx1-induced transcriptional activation regulates mir-106b biogenesis trna-derived small rna mouse piwi-interacting rnas mir-200c-3p adjacent activated wnt-beta/catenin rna-induced silencing complex vault-derived small rnas spry1/erk/nf-kappa illumina-based ribomethseq approach author information authors trna-derived small rnas rna methylation-mediated repression rna-derived small rnas yaguang zhang melittin-induced selective suppression mir-589-5p promotes excessive mir-25-3p maturation high-throughput sequencing platform cp-rna-seq method

Questions {❓}

Dietary delivery: a new avenue for microRNA therapeutics?

Schema {🗺️}

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         description:Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells. Small RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. Current evidence suggest that small RNAs can also have diverse modifications to their nucleotide composition that affect their stability as well as their capacity for nuclear export, and these modifications are relevant to their capacity to drive molecular signaling processes relevant to biogenesis, cell proliferation and differentiation. In this review, we highlight the molecular characteristics and cellular functions of small RNA and their modifications, as well as current techniques for their reliable detection. We also discuss how small RNA modifications may be relevant to the clinical applications for the diagnosis and treatment of human health conditions such as cancer.
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            Pseudouridine
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            Cancer Research
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      headline:Small RNA modifications: regulatory molecules and potential applications
      description:Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells. Small RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. Current evidence suggest that small RNAs can also have diverse modifications to their nucleotide composition that affect their stability as well as their capacity for nuclear export, and these modifications are relevant to their capacity to drive molecular signaling processes relevant to biogenesis, cell proliferation and differentiation. In this review, we highlight the molecular characteristics and cellular functions of small RNA and their modifications, as well as current techniques for their reliable detection. We also discuss how small RNA modifications may be relevant to the clinical applications for the diagnosis and treatment of human health conditions such as cancer.
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         RNA modifications
         MicroRNA
         PIWI-interacting RNA
         tRNA-derived small RNA
         N6-methyladenosine
         2′-O-methylation
         5-Methylcytosine
         Pseudouridine
         Oncology
         Hematology
         Cancer Research
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      name:State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics and Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

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