
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders - PMC
Description:
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown. By comparing gene ...
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Keywords {π}
nsun, trna, doi, cells, trnas, rna, stress, pubmed, google, scholar, mouse, cell, human, methylation, supplementary, pmc, fragments, article, fig, free, angiogenin, cytosine, data, cleavage, mice, number, brain, response, protein, sequencing, cellular, wildtype, translation, size, methylated, loss, genes, control, dna, min, brains, gene, oxidative, skin, performed, bars, blanco, increased, stressinduced, reads,
Topics {βοΈ}
cca[cca] ends 3β²/cca-tagged trna fragments caa alexa fluor-conjugated mediates myc-induced proliferation nsun2-trna cross-linked sites pol iii chip-seq stress-induced translational repression pmc beta search goat polyclonal anti-sk1 goat polyclonal anti-eif3Ξ· trna-derived small rnas pooled full-length trna cca 3β²-ends hrp-conjugated secondary antibodies trna-derived fragments target heavily modified post-transcriptionally nonsense-mediated decay pathway post-transcriptional methylation contributes cr-uk ci genomics goat polyclonal anti-4et stress-induced trna cleavage zymocin-induced cell death inhibit trnaβprotein interactions 2-ΞΌm-pore nitrocellulose membrane stress-induced rna cleavage goat polyclonal anti-eif4ai site-specific cytosine-5 methylation trna-derived rna fragments small-molecule inhibitor n65828 stress-induced cell death rna-induced silencing machinery de/users/anders/htseq/ gfp-tagged fluc construct generate bisulfite-seq libraries single-stranded rna oligos real-time pcr amplification autosomal-recessive intellectual disability gfp-tagged fluc variants methylation-dependent trna cleavage full-length c48/49g reporter constructs flucnm-gfp genome-wide expression studies aberrant post-transcriptional methylation pre-synaptic marker synapsin stress-induced nsun2+/β cells insoluble gfp-protein aggregates post-synaptic marker psd95 nsun2-mediated cytosine-5 methylation single-stranded dna probes
Questions {β}
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Analytics and Tracking {π}
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Emails and Hosting {βοΈ}
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