
NCBI . NLM . NIH . GOV {
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Title[redir]:
Origins and evolving functionalities of tRNA-derived small RNAs - PMC
Description:
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are among the most ancient small RNAs in all domains of life and are generated by the cleavage of tRNAs. Emerging studies have begun to reveal the versatile roles of tsRNAs in fundamental biological ...
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Keywords {🔍}
rna, doi, google, scholar, pubmed, pmc, article, free, tsrnas, trna, tsrna, small, rnas, cell, trnas, modifications, biol, function, trnaderived, biogenesis, figure, cleavage, res, specific, cells, acids, fragments, protein, nucleic, stress, mol, life, world, translation, argonaute, nat, translational, rnase, sci, ribosome, ribozymes, functions, proteins, modification, regulation, human, enzymes, ancient, functionality, binding,
Topics {✒️}
predicted stem–bulge–stem–loop structures including cross-tissue/cross-species regulation high-fat diet-exposed males tsrna-rnp-based eif sequestration angiogenin-induced trna fragments intermolecular rna g-quadruplexes trna-derived small rnas ate1-mediated post-translational arginylation cap-clip acid pyrophosphatase pmc beta search kluyveromyces lactis gamma-toxin mediate cross-kingdom regulation trna-derived fragments target cloverleaf-shaped secondary structure food-derived small rnas high-throughput rna sequencing trna-derived small rna trna-derived fragment competes yrna-derived small rnas rrna-derived small rnas trna-derived rna fragments trmt10a-mediated n1-methylguanine arginyl-trna–protein transferase data analyses high-dimensional lower-dimensional latent space g-quadruplex structures contribute excellent research/clinical opportunity induce stress granule glossary aminoacyl-trna synthetases mediate post-transcriptional silencing paternal low-protein diet enzymes targeting double-stranded post-translational modification mediated standard rna-seq protocols determine protein-binding potential rna-seq library preparation tsrna-mediated translational regulation rna-catalyzed rna polymerization time-resolved nmr monitoring site-specific rna methylation site-specific rna modifications derived small rnas foreign dna/rna invasions infection-induced 5′-half molecules versatile protein-based enzymes rna-dependent rna polymerase dnmt2-dependent trna methylation prevent site-specific cleavage stress-induced 5′tsrnaval stress-induced 3′tsrnathr
Questions {❓}
- (B) Known and predicted (?
- , expression level, cleavage patterns, RNA modifications) for deep learning and clinical translational applications?
- Broecker F and Moelling K (2019) What viruses tell us about evolution and immunity: beyond Darwin?
- Could tsRNAs mediate cross-species regulation between food and the microbiome, or between the microbiome and the host?
- Diener TO (1989) Circular RNAs: relics of precellular evolution?
- Do RNA modifications regulate tsRNA intracellular sorting, compartmentalization, and functionality in conjunction with associated RNA-binding proteins?
- How can tsRNA levels be experimentally manipulated without affecting their tRNA precursors?
- How many more (modified) tsRNAs can be discovered with improved RNA sequencing methods?
- Is the principle of the functionality of each tsRNA universal or context-dependent?
- To what extent do RNA modifications and 3D RNA structures affect the functions of tsRNAs, in addition to their sequences?
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