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We began analyzing https://link.springer.com/article/10.1007/s11010-025-05340-w, but it redirected us to https://link.springer.com/article/10.1007/s11010-025-05340-w. The analysis below is for the second page.

Title[redir]:
Emerging trends in cardiovascular diseases: the impact of ferroptosis and cuproptosis on cardiomyocyte death | Molecular and Cellular Biochemistry
Description:
Cardiovascular diseases (CVDs) comprise a range of conditions affecting the heart and vasculature, encompassing ischemic heart disease (IHD), stroke, heart failure (HF), peripheral and aortic diseases, arrhythmias, and valvulopathy. Notably, the high prevalence rates of CVDs among younger populations warrant concern, emphasizing the importance of prevention and treatment. In recent years, ferroptosis, a novel form of cell death, has attracted significant research interest across various diseases. Similarly, cuproptosis, another cell death mechanism resulting from copper ion accumulation, has also been extensively studied. Cell death plays a crucial role in the development and maintenance of organisms, with both ferroptosis and cuproptosis closely associated with cell metabolism, signaling pathways, and drug resistance. Emerging evidence suggests that ferroptosis and cuproptosis are closely linked to the occurrence and progression of various diseases, including CVDs. The death of myocardial cells is pivotal in the pathophysiology of CVDs, with the roles of ferroptosis and cuproptosis in this process increasingly recognized. This article aims to summarize the molecular mechanisms and interactions of ferroptosis and cuproptosis, as well as their potential as novel targets for CVD treatment.

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Keywords {🔍}

pubmed, ferroptosis, copper, article, google, scholar, cuproptosis, cell, cas, iron, death, central, mitochondrial, role, heart, levels, cells, myocardial, wang, proteins, cardiovascular, metabolism, mechanisms, zhang, disease, cardiac, diseases, treatment, cancer, chen, lipid, cellular, protein, therapeutic, stress, cycle, atherosclerosis, ions, gsh, failure, potential, ros, slca, expression, tca, diabetic, fdx, patients, liu, homeostasis,

Topics {✒️}

akt/gsk-3ß/fyn pathway oncogenic-ras-harboring cancer cells advanced glycation end-products article download pdf atf3/spi1/slc31a1 pathway amp-activated protein kinase yap/atp7a signaling pathway hif-1α/hmox1 axis [141] hif-1α/hmox1 axis platinum-based chemotherapy response nf-κb signaling pathway age-dependent degenerative processes age-induced cell death hyperglycemia-driven pathogenic abnormality copper-induced cell death high-affinity copper transporter age-treated endothelial cells metal-mediated cell death age-cucl2-induced cuproptosis ela-apelin receptor axis secrete pro-inflammatory cytokines es-cu-induced cuproptosis il-6/stat3/gpx4 signaling iron-ion dependent form postn/p53/slc7a11 axis ferritin heavy chain atf3/spi1 pathway cuproptosis-induced cell death iron-death-specific marker [22] myocellular copper-trafficking proteins transition-metal-binding properties iron-dependent lipid peroxidation chemotherapeutic agent treating cystine transporter slc7a11/xct cuproptosis-related characteristic genes nrf2/ho-1 signaling pathway tca cycle-related enzymes population-based cohort study constructing fth-deficient mice dihydrolipoamide s-acetyltransferase apoptosis-specific iron inhibitors converting phospholipid hydroperoxides retinal developmental abnormalities polyunsaturated fatty acids xc/gsh/gpx4 axis cysteine deprivation-induced ferroptosis months post-diabetes onset polyunsaturated-fatty-acid alongside targeting genes ferritin light chain

Questions {❓}

Anagnostis P, Karagiannis A, Kakafika AI, Tziomalos K, Athyros VG, Mikhailidis DP (2009) Atherosclerosis and osteoporosis: age-dependent degenerative processes or related entities?
Consequently, could the co-regulation of these two forms of cell death through the p53 gene offer a novel therapeutic approach?

Schema {🗺️}

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