
NCBI . NLM . NIH . GOV {
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Title[redir]:
Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes - PMC
Description:
Ischaemic heart disease (IHD) is the leading cause of death worldwide. Although myocardial cell death plays a significant role in myocardial infarction (MI), its underlying mechanism remains to be elucidated. To understand the progression of MI and ...
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Keywords {🔍}
doi, ferroptosis, cells, cell, gpx, pubmed, google, scholar, fig, death, pmc, article, free, analysis, lipid, cysteine, levels, data, ros, cardiac, myocardial, heart, protein, cardiomyocytes, nrvms, gsh, rsl, supplementary, inhibition, glutathione, depletion, pathways, viability, sirna, mice, mrna, stage, downregulated, deprivation, fer, treated, pathway, expression, twosided, students, ttest, nrf, usa, mouse, peroxidation,
Topics {✒️}
easy-nlc1000/ltq orbitrap elite p62-keap1-nrf2 pathway protects sprague-dawley rat pups adipose-derived stem cells jab1-mediated nuclear export high-sucrose diet showed doxorubicin-induced mouse model58 pmc beta search cysteine deprivation-induced ferroptosis63 gcn2-eif2α-atf4 pathway zeb1-mediated lipogenic reprogamming53 aif-mediated cell death protein-protein interaction networks ki67-lineage tracing found single-cell mrna sequencing injured cardiomyocytes-derived exosomes affect rsl3-induced ferroptosis rsl3-induced cell death sham-operated animals underwent m-mlv reverse transcriptase qrt-pcr analyses suggested lc-ms/ms analysis cystine/glutamate transporter cardiac ischaemia-reperfusion injury cysteine deficiency-induced ferroptosis epithelial-mesenchymal transition emt-related transcription factors serum-free medium cysteine deprivation-induced ferroptosis p53-mediated tumour suppression rna-seq results showed gpx4 inhibitor-induced ferroptosis growth factor signalling publisher site pdf gpx4-depleted cells underwent mesenchymal marker cdh2 heart failure induced license information pmcid gpx4 knockdown-induced ferroptosis prevent heart failure volcano plot shows cardiac stem cells mir-142a-5p cell death induced induced cell death ferroptotic cell death anti-hif-1α tandem mass tag breast cancer cells tnf/birinapant/zvad-fmk
Questions {❓}
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- Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
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