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Keywords {🔍}

doi, nrf, lipid, ferroptosis, pubmed, google, scholar, cell, free, pmc, peroxidation, article, iron, death, reactive, target, cancer, genes, role, disease, targets, biol, ferroptotic, key, pathway, cells, redox, critical, species, form, metabolism, chem, factor, antioxidant, peroxides, cascade, inhibition, transcription, signaling, proteins, including, number, increased, glutathione, gpx, response, expression, important, diseases, downstream,

Topics {✒️}

protein 1-cullin1-rbx1/β-transducin repeat cap'n'collar transcription factor oncogenic-ras-harboring cancer cells peroxisome proliferator-activated receptor-γ p62-keap1-nrf2 pathway protects nrf2-regulated ppar{gamma} expression stress-inducible transcription factor beta-unsaturated aldehyde 4-hydroxy-2-nonenal endogenous stress-induced modifications pmc beta search cystine/glutamate transporter xct nrf2-lipid peroxidation-ferroptosis axis gamma glutamyl-cysteine synthetase e3-ubiquitin ligase complexes cell-line selectivity improves poly-unsaturated fatty acids sorafenib-induced cytoskeletal rearrangement genotype-selective antitumor agents glucose metabolism/napdh regeneration identified ferroptosis-inducing compounds integral anti-ferroptotic reducer glutathione-s-transferase p1-1 nrf2-regulated genes induced nrf2-mediated transcriptional pathway oxidative stress-inducible genes cyclopentenone prostaglandin 15-deoxy-δ iron-dependent cell death transcription factor nrf2 nrf2-target marker genes lipid peroxidation-related proteins lipid peroxide-driven form ferroptosis-inducing agents identified prevent erastin-induced ferroptosis glutathione-s-transferases pi 1 treating ferroptosis-related pathologies hepatocellular carcinoma cells altered iron import/export hypoxia-inducible factor publisher site pdf gsh-based redox reactions high throughput screening glutamate-cysteine ligase ferroptosis-resistant cancer types free iron exists p53-driven cancers breast cancer res anti-tumor agents [3] form hydroxyl/peroxyl radicals lipogenic gene expression human aldehyde dehydrogenases

Questions {❓}

• Unsolved mysteries: how does lipid peroxidation cause ferroptosis?

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