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Keywords {🔍}

pubmed, pyroptosis, article, google, scholar, cell, cas, cells, cancer, central, death, caspase, apoptosis, tumor, pediatric, treatment, zhang, wang, osteosarcoma, pathway, cancers, activation, inflammasome, gsdme, nlrp, therapy, expression, drugs, liu, induce, protein, release, oncol, role, gasdermin, mechanisms, neuroblastoma, gsdmd, human, chen, pathways, therapies, lymphoma, membrane, cleavage, leukemia, patients, immune, nat, immunol,

Topics {✒️}

mir-181/sirt1/pgc-1α/nrf2 signaling pathway sirt1/pgc-1α/nrf2 pathway mir-142a-3p enhances flaa c-jun n-terminal kinase irak1/nf-kappab signaling pathway p53/p21/cyclin b1 pathway named n-bm-mscs-exo dpp8/dpp9 inhibitor-induced pyroptosis induce g2/m-phase arrest inducing g2/m-phase arrest el-deiry ws article download pdf multi-anti-tumor pharmacological effects calcium-sensing receptor regulates hypoxic bm-mscs-exo nonselective dpp-inhibitor val-boropro meg3/nlrp3/caspase-1/gsdmd pathway bone marrow-derived macrophages h-bm-mscs-exo assist chemotherapy-induced icd chemotherapy-induced cell death double-strand dna break copper-induced cell death central nervous system nlrp3-mediated il-1β activation oncology small-molecule drugs severe methotrexate-induced toxicity noncanonical pyroptotic pathway pediatric high-grade glioma radiation fosters dose-dependent recurrent/refractory cns tumors chemotherapy drug-induced pyroptosis n-terminal gasdermin domain higher-risk myelodysplastic syndrome including caspase-3/8-mediated pathway trigger mitochondria-mediated apoptosis radiation-mediated intestinal injury potent anti-tumor effect synergistic anti-tumor effect ras-mapk pathway [117] gsdme-dependent cell death calcium-influx-dependent histamine [132] nf-κb signaling pathways death-inducing signaling complex triple-negative breast cancer gram-negative bacterial infections cytokine release syndrome chemotherapy-induced tissue damage dhodh-mediated ferroptosis defence central south university

Questions {❓}

• Lighting a fire: can we harness pyroptosis to ignite antitumor immunity?
• Neoadjuvant treatment for resectable and borderline resectable pancreatic cancer: Chemotherapy or chemoradiotherapy?
• Osteosarcoma treatment—Where do we stand?
• What’s new in bone forming tumours of the skeleton?

Schema {🗺️}

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         description:Pediatric cancers are the driving cause of death for children and adolescents. Due to safety requirements and considerations, treatment strategies and drugs for pediatric cancers have been so far scarcely studied. It is well known that tumor cells tend to progressively evade cell death pathways, which is known as apoptosis resistance, one of the hallmarks of cancer, dominating tumor drug resistance. Recently, treatments targeting nonapoptotic cell death have drawn great attention. Pyroptosis, a newly specialized form of cell death, acts as a critical physiological regulator in inflammatory reaction, cell development, tissue homeostasis and stress response. The action in different forms of pyroptosis is of great significance in the therapy of pediatric cancers. Pyroptosis could be induced and consequently modulate tumorigenesis, progression, and metastasis if treated with local or systemic therapies. However, excessive or uncontrolled cell death might lead to tissue damage, acute inflammation, or even cytokine release syndrome, which facilitates tumor progression or recurrence. Herein, we aimed to describe the molecular mechanisms of pyroptosis, to highlight and discuss the challenges and opportunities for activating pyroptosis pathways through various oncologic therapies in multiple pediatric neoplasms, including osteosarcoma, neuroblastoma, leukemia, lymphoma, and brain tumors.
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         Cancer Research
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      name:Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, China
      name:Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, China
      name:Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, China

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