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Title:
A Systems Biology Approach to Iron Metabolism | SpringerLink
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Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways...
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Keywords {π}
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Topics {βοΈ}
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- When is a heme transporter not a heme transporter?
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ScholarlyArticle:
headline:A Systems Biology Approach to Iron Metabolism
pageEnd:225
pageStart:201
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-2095-2.jpg
genre:
Biomedical and Life Sciences
Biomedical and Life Sciences (R0)
isPartOf:
name:A Systems Biology Approach to Blood
isbn:
978-1-4939-2095-2
978-1-4939-2094-5
type:Book
publisher:
name:Springer New York
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Julia Chifman
affiliation:
name:Wake Forest School of Medicine
address:
name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
type:PostalAddress
type:Organization
type:Person
name:Reinhard Laubenbacher
affiliation:
name:University of Connecticut Health Center
address:
name:Center for Quantitative Medicine, University of Connecticut Health Center, Farmington, USA
type:PostalAddress
type:Organization
type:Person
name:Suzy V. Torti
affiliation:
name:University of Connecticut Health Center
address:
name:Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
keywords:Hydroxyl radical, Heme, Phagocytose, Constant decay rate, Petri nets, Homeostasis, Transferrin, Erythroid bone marrow, Erythrocytes, Phagocytosis, Plasma, Continuous versus discrete models
description:Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several scales, ranging from the subcellular to the organismal. This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in iron metabolism and their underlying causes.
datePublished:2014
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name:Wake Forest School of Medicine
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name:Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, USA
name:Center for Quantitative Medicine, University of Connecticut Health Center, Farmington, USA
name:Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, USA
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