We are analyzing https://link.springer.com/article/10.1186/s12964-023-01267-1.

Title:
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death | Cell Communication and Signaling
Description:
Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling cascades and molecular mechanisms. RCD is implicated in fundamental processes such as organ production and tissue remodeling, removing superfluous structures or cells, and regulating cell numbers. Previous studies have not been able to reveal the complete mechanisms, and novel methods of RCD are constantly being proposed. Two metal ions, iron (Fe) and copper (Cu) are essential factors leading to RCDs that not only induce ferroptosis and cuproptosis, respectively but also lead to cell impairment and eventually diverse cell death. This review summarizes the direct and indirect mechanisms by which Fe and Cu impede cell growth and the various forms of RCD mediated by these two metals. Moreover, we aimed to delineate the interrelationships between these RCDs with the distinct pathways of ferroptosis and cuproptosis, shedding light on the complex and intricate mechanisms that govern cellular survival and death. Finally, the prospects outlined in this review suggest a novel approach for investigating cell death, which may involve integrating current therapeutic strategies and offer a promising solution to overcome drug resistance in certain diseases. Video Abstract
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Keywords {🔍}

pubmed, article, iron, google, scholar, cell, copper, ferroptosis, cas, death, central, cells, cancer, apoptosis, cuproptosis, protein, autophagy, ros, pyroptosis, mitochondrial, lipid, caspase, induces, addition, proteins, necroptosis, stress, dna, pathway, chen, peroxidation, biol, induce, gsh, chem, wang, complex, role, including, induced, diseases, oxidative, gpx, proteasome, inhibition, degradation, zhang, promotes, study, ions,

Topics {✒️}

rna-binding protein elavl1/hur oncogenic-ras-harboring cancer cells fenton-reaction-acceleratable magnetic nanoparticles lpcat3 esterifies pufa-coa ripk1/ripk3/mlkl necroptotic pathway article download pdf ripk1/ripk3/mlkl pathway tom20-bax-caspase3-gsdme pathway imidazole-functionalised calix[4]arenes metal-based synthetic nucleases human low-density lipoprotein mammary tumor mda-mb-435 dual-core copper center heat-stable polypeptide component increases mitophagy-dependent ros caspase-8-dependent pyroptotic pathway redox-mediated cell death anti-pd-l1 antibody nutrient-deprived cancer cells atp-dependent proteolytic system metal-induced oxidative stress transfusion-dependent myelodysplastic syndromes causing light-scattering aggregates glioma-induced brain edema cuproptosis-related sterile inflammation dna double-strand breaks cells secreted ifn-γ single-cell transcriptome level copper-mediated cell death p53-mediated metabolic activities p53-sat1-alox15 pathway ros-dependent rcd driven ifn-γ induces apoptosis catalysis-based specific detection dihydrolipoamide s-acetyltransferase scrna-seq analysis proved long-term iron inadequacy transferrin receptor-mediated endocytosis ros-induced stress responses covalently cross-linked multimers transition metals supplementation/deficiency sanchez-niño md p53-mediated ferroptotic responses copper-induced cell death human cell biology iron-mediated lipid peroxidation low-molecular-weight antioxidants nlrp3/asc/caspase1 complex autophagy-dependent cell death released ifn-γ reduces

Questions {❓}

Cuproptosis: p53-regulated metabolic cell death?
Does copper also contribute to necroptosis?
Free copper ions in the cell?

Schema {🗺️}

WebPage:
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         description:Regulated cell death (RCD) is a regulable cell death that involves well-organized signaling cascades and molecular mechanisms. RCD is implicated in fundamental processes such as organ production and tissue remodeling, removing superfluous structures or cells, and regulating cell numbers. Previous studies have not been able to reveal the complete mechanisms, and novel methods of RCD are constantly being proposed. Two metal ions, iron (Fe) and copper (Cu) are essential factors leading to RCDs that not only induce ferroptosis and cuproptosis, respectively but also lead to cell impairment and eventually diverse cell death. This review summarizes the direct and indirect mechanisms by which Fe and Cu impede cell growth and the various forms of RCD mediated by these two metals. Moreover, we aimed to delineate the interrelationships between these RCDs with the distinct pathways of ferroptosis and cuproptosis, shedding light on the complex and intricate mechanisms that govern cellular survival and death. Finally, the prospects outlined in this review suggest a novel approach for investigating cell death, which may involve integrating current therapeutic strategies and offer a promising solution to overcome drug resistance in certain diseases.
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      headline:Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
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