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We are analyzing https://www.nature.com/articles/s41569-021-00520-9.

Title:
Electroimmunology and cardiac arrhythmia | Nature Reviews Cardiology
Description:
Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent owing to the increasing age and body mass of the general population, because both are risk factors for arrhythmia. Many of the underlying conditions that give rise to arrhythmia — including atrial fibrillation and ventricular arrhythmia, which frequently occur in patients with acute myocardial ischaemia or heart failure — can have an inflammatory component. In the past, inflammation was viewed mostly as an epiphenomenon associated with arrhythmia; however, the recently discovered inflammatory and non-canonical functions of cardiac immune cells indicate that leukocytes can be arrhythmogenic either by altering tissue composition or by interacting with cardiomyocytes; for example, by changing their phenotype or perhaps even by directly interfering with conduction. In this Review, we discuss the electrophysiological properties of leukocytes and how these cells relate to conduction in the heart. Given the thematic parallels, we also summarize the interactions between immune cells and neural systems that influence information transfer, extrapolating findings from the field of neuroscience to the heart and defining common themes. We aim to bridge the knowledge gap between electrophysiology and immunology, to promote conceptual connections between these two fields and to explore promising opportunities for future research. In this Review, Nahrendorf and colleagues discuss the electrophysiological properties of leukocytes and how these cells relate to conduction in the heart, aiming to bridge the knowledge gap between electrophysiology and immunology and to explore the roles of leukocytes in cardiac conduction and arrhythmia.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
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  • Science

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Custom-built

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🚀🌠 Tremendous Traffic: 10M - 20M visitors per month


Based on our best estimate, this website will receive around 16,942,715 visitors per month in the current month.

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Display Ads {🎯}

$213,500 per month
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Keywords {🔍}

pubmed, scholar, google, article, cas, central, heart, atrial, fibrillation, cardiac, cardiol, patients, myocardial, res, nature, ventricular, cell, arrhythmias, circulation, infarction, inflammation, cells, macrophages, circ, fibrosis, nat, physiol, immunol, rhythm, med, activation, cardiovasc, study, human, mouse, clin, electrophysiol, arrhythmia, immune, channel, rev, sci, risk, failure, disease, review, research, myocarditis, coll, association,

Topics {✒️}

nature portfolio journals permissions reprints emergency medical services nature portfolio privacy policy editing advertising anti-ssa/ro52 autoantibodies blocking scientific statement tumor necrosis factor-α author information authors social media regional variation material research support tumor necrosis factor-alpha german research foundation voltage-gated potassium channel renin-angiotensin system antagonists enhanced fibroblast-myocyte interactions transforming growth factor-β dynamic nature il-1β enhances susceptibility store-operated ca2+ entry cardiovascular research amiodarone anti-arrhythmic therapy macrophage-derived matrix metalloproteinases anti-ro/ssa antibodies antigen-presenting dendritic cells nonlinear current-voltage relationships ion channel-centric focus 2017 aha/acc/hrs guideline 2018 acc/aha/hrs guideline 2014 aha/acc/hrs guideline pdgf-a-mediated fibrosis store-operated calcium entry st-elevation myocardial infarction c-reactive protein concentrations author correspondence tissue-specific macrophage responses t-cell-mediated phenomenon tumor necrosis factor nature+ nature 588 nature 395 nature 454 nature 499 nature 573 nature anti-programmed cell death-1 fibroblast-myocyte electrotonic coupling

Questions {❓}

  • Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?
  • Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation?
  • May fever trigger ventricular fibrillation?
  • Mechanisms of fibrillation: neurogenic or myogenic?
  • Myocarditis and cardiac channelopathies: a deadly association?

Schema {🗺️}

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