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Title[redir]:
Current Opinion in Cardiology
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model. Recent findings The electrophysiological hallmark of cells and tissues isolated from failing hearts is prolongation of action potential duration (APD) and conduction slowing. In human studies and a number of animal models of heart failure, functional downregulation of K currents and alterations in depolarizing Na and Ca currents and transporters are demonstrated. Alterations in intercellular ion channels and extracellular matrix contribute to heterogeneity of APD and conduction slowing. The changes in cellular and tissue function are regionally heterogeneous, particularly in the DHF. Furthermore, β-adrenergic signaling and modulation of ionic currents is blunted in heart failure. CRT partially reverses the DHF-induced downregulation of K current and improves Na channel gating. CRT significantly improves Ca homeostasis, especially in lateral myocytes, and restores the DHF-induced blunted β-adrenergic receptor responsiveness. CRT abbreviates DHF-induced prolongation of APD in the lateral myocytes, reduces the left ventricular regional gradient of APD and suppresses development of early afterdepolarizations. Summary CRT partially restores DHF-induced electrophysiological remodeling, abnormal Ca homeostasis, blunted β-adrenergic responsiveness, and regional heterogeneity of APD, and thus may suppress ventricular arrhythmias and contribute to the mortality benefit of CRT as well as improving mechanical performance of the heart....
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Keywords {🔍}
journal, heart, crt, apd, issue, failure, dhfinduced, access, subscribe, alerts, authors, abstract, remodeling, current, conduction, ventricular, currents, βadrenergic, blunted, log, register, logo, articles, issues, arrhythmias, electrical, failing, buy, cellular, left, dhf, electrophysiological, prolongation, slowing, downregulation, alterations, contribute, heterogeneity, partially, improves, homeostasis, lateral, myocytes, restores, responsiveness, regional, text, subscribers, request, browse,
Topics {✒️}
blunted β-adrenergic responsiveness dhf-induced downregulation β-adrenergic signaling crt partially reverses journal authors submit abnormal ca homeostasis full text access suppress ventricular arrhythmias cardiac resynchronization therapy action potential duration intercellular ion channels improving mechanical performance artificial intelligence training extracellular matrix contribute etoc alerts electrical remodeling service request 800-638-3030 register subscribe electrophysiological hallmark individual subscribers log journal tables abstract arrhythmias issue heart failure depolarizing na ca currents website subscribe journal failing hearts functional downregulation restores regional heterogeneity center submit dhf recent findings tissues isolated human studies animal models tissue function regionally heterogeneous blunted lateral myocytes suppresses development early afterdepolarizations mortality benefit email inbox rights reserved data mining crt conduction slowing
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