
NCBI . NLM . NIH . GOV {
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Title[redir]:
Interleukin 10 Inhibits Bone Marrow Fibroblast Progenitor Cell-mediated Cardiac Fibrosis in Pressure Overloaded Myocardium - PMC
Description:
Activated fibroblasts (myofibroblasts; myoFBs) play critical role in cardiac fibrosis; however, their origin in the diseased heart remains unclear warranting further investigation. Recent studies suggest the contribution of bone marrow fibroblast ...
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Keywords {🔍}
cells, doi, mice, cardiac, bone, heart, fibrosis, marrow, bmfpcs, ilko, expression, tgfβ, pubmed, google, scholar, mirna, bmfpc, cell, pmc, progenitor, fibroblast, article, treatment, free, inhibits, tgfβinduced, mobilization, figure, transdifferentiation, signaling, significantly, fibroblasts, myofibroblasts, homing, chimeric, tac, tacinduced, fibrotic, mirnas, prominin, function, myocardium, role, αsma, myocardial, pressure, data, days, reduced, performed,
Topics {✒️}
tgfβ-induced bm-fpc trans-differentiation inhibits bm-fpc trans-differentiation c57bl/6-tg[cag-egfp]10sb/ experimental autoimmune myocarditis induce bm-fpc trans-differentiation bm-fpc-mediated cardiac fibrosis tac-induced bm-fpc mobilization il10 inhibits trans-differentiation tac-induced bm-fpc recruitment bone marrow-derived cells il10 inhibits tgfβ-induced tac-induced bm-fpcs mobilization american heart association-grant mirna-21 suppresses tgfβ-induced inhibits bm-fpc activation tgfβ-induced enhanced expression drosha-mediated mirna-21maturation 28 bm-fpc-mediated fibrosis bone marrow post-tac bm-fpc trans-differentiation α-smooth muscle actin tgfβ-induced bm-fpc reduced bm-fpc mobilization tgfβ-induced fibrotic gene cd45-positive progenitor cells tgfβ-induced fibrotic signaling wt bone marrow-transplantation nonparametric kruskal-wallis test mirna-array data showed facilitates bm-fpc activation il10 ko bm-fpc evaluated bm-fpc mobilization male transgenic egfp-expressing tgfβ-smad signaling plays serum-free imdm media pmc beta search recipient female il10-knockout failing hearts trans-differentiated bm-depleted il10ko mice double-positive cells suggest tac-induced cardiac fibrosis bm-fpcs trans-differentiation myofibroblast-related protein expression tgfβ-induced αsma expression reduced bm-fpc homing erk-map kinase isotype-matched igg antibodies extra-cardiac cells contribute il10 ko bm-fpcs rt-pcr data showed
Questions {❓}
- Chemokines and inflammation in heart disease: Adaptive or maladaptive?
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