We are analyzing https://link.springer.com/article/10.1186/s40425-016-0152-y.

Title:
Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy | Journal for ImmunoTherapy of Cancer
Description:
Immune-checkpoint blocking antibodies have demonstrated objective antitumor responses in multiple tumor types including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). In melanoma, an increase in overall survival has been demonstrated with anti-CTLA-4 and PD-1 inhibition. However, a plethora of immune-mediated adverse events has been reported with these agents. Immune-mediated cardiotoxicity induced by checkpoint inhibitors has been reported in single cases with variable presentation, including myocarditis and pericarditis. Among six clinical cancer centers with substantial experience in the administration of immune-checkpoint blocking antibodies, eight cases of immune-related cardiotoxicity after ipilimumab and/or nivolumab/pembrolizumab were identified. Diagnostic findings, treatment and follow-up are reported. A large variety of cardiotoxic events with manifestations such as heart failure, cardiomyopathy, heart block, myocardial fibrosis and myocarditis was documented. This is the largest case series to date describing cardiotoxicity of immune-checkpoint blocking antibodies. Awareness, monitoring of patients with pre-existing cardiac disorders and prompt evaluation by the treatment team is essential. Treatment including application of steroids is critical for patient safety.
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Keywords {🔍}

pubmed, article, melanoma, ipilimumab, cardiac, patient, google, scholar, cancer, myocarditis, patients, treatment, case, metastatic, cas, treated, including, clinical, heart, failure, antibodies, immunerelated, disease, left, central, therapy, institutional, antipd, tumor, review, effects, ventricular, ctla, events, cardiomyopathy, checkpoint, myocardial, pembrolizumab, immunotherapy, adverse, fibrosis, board, side, center, university, revealed, developed, cardiotoxicity, blocking, hodi,

Topics {✒️}

dana-farber cancer institute friedrich-alexander-university erlangen-nürnberg immune-checkpoint blocking antibodies immune-related adverse events anti-programmed-death-receptor-1 treatment immune-related adverse event immune-mediated adverse events rectus muscle wild-type immune-related cardiac syndromes pd1 blocking immunotherapy immune-checkpoint antibody treatment immune-related toxicity induced immune-related toxicity experienced autologous anti-mage-a3 article download pdf past medical history immune-mediated etiology triggered azadeh tajmir-riahi anti-pd1 antibody pembrolizumab immune-mediated cardiotoxicity induced ctla-4 blocking antibody pre-existing cardiac disorders randomised dose-comparison cohort ipilimumab-refractory advanced melanoma ventricular tachycardia/ventricular fibrillation pre-existent cardiac pathology bacterial/fungal cultures ruled suggest stress-induced ischemia cancer lucie heinzerling prior cardiac history pd-1 receptor-deficient mice institutional review board immune-related toxicity anti-ctla-4 antibodies [15–20] anti-ctla-4 antibodies immunotherapy cancer 4 immune-related cardiotoxicity checkpoint inhibitor therapy cardiologic side effects immune checkpoint blockade immune-induced myocarditis immune-related colitis fixed perfusion defect institutional review boards immunostimulatory monoclonal antibody phase ii decog-study microscopic findings including anti-pd1 antibodies anti-pd1 antibodies [10 renal cell cancer

Schema {🗺️}

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         headline:Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy
         description:Immune-checkpoint blocking antibodies have demonstrated objective antitumor responses in multiple tumor types including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). In melanoma, an increase in overall survival has been demonstrated with anti-CTLA-4 and PD-1 inhibition. However, a plethora of immune-mediated adverse events has been reported with these agents. Immune-mediated cardiotoxicity induced by checkpoint inhibitors has been reported in single cases with variable presentation, including myocarditis and pericarditis. Among six clinical cancer centers with substantial experience in the administration of immune-checkpoint blocking antibodies, eight cases of immune-related cardiotoxicity after ipilimumab and/or nivolumab/pembrolizumab were identified. Diagnostic findings, treatment and follow-up are reported. A large variety of cardiotoxic events with manifestations such as heart failure, cardiomyopathy, heart block, myocardial fibrosis and myocarditis was documented. This is the largest case series to date describing cardiotoxicity of immune-checkpoint blocking antibodies. Awareness, monitoring of patients with pre-existing cardiac disorders and prompt evaluation by the treatment team is essential. Treatment including application of steroids is critical for patient safety.
         datePublished:2016-08-16T00:00:00Z
         dateModified:2016-08-16T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s40425-016-0152-y
         keywords:
            Checkpoint inhibitor
            Immune-related adverse events
            Melanoma
            Immunotherapy
            Myocarditis
            Cardiomyopathy
            Ipilimumab
            Nivolumab
            Pembrolizumab
            Oncology
            Immunology
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ScholarlyArticle:
      headline:Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy
      description:Immune-checkpoint blocking antibodies have demonstrated objective antitumor responses in multiple tumor types including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). In melanoma, an increase in overall survival has been demonstrated with anti-CTLA-4 and PD-1 inhibition. However, a plethora of immune-mediated adverse events has been reported with these agents. Immune-mediated cardiotoxicity induced by checkpoint inhibitors has been reported in single cases with variable presentation, including myocarditis and pericarditis. Among six clinical cancer centers with substantial experience in the administration of immune-checkpoint blocking antibodies, eight cases of immune-related cardiotoxicity after ipilimumab and/or nivolumab/pembrolizumab were identified. Diagnostic findings, treatment and follow-up are reported. A large variety of cardiotoxic events with manifestations such as heart failure, cardiomyopathy, heart block, myocardial fibrosis and myocarditis was documented. This is the largest case series to date describing cardiotoxicity of immune-checkpoint blocking antibodies. Awareness, monitoring of patients with pre-existing cardiac disorders and prompt evaluation by the treatment team is essential. Treatment including application of steroids is critical for patient safety.
      datePublished:2016-08-16T00:00:00Z
      dateModified:2016-08-16T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s40425-016-0152-y
      keywords:
         Checkpoint inhibitor
         Immune-related adverse events
         Melanoma
         Immunotherapy
         Myocarditis
         Cardiomyopathy
         Ipilimumab
         Nivolumab
         Pembrolizumab
         Oncology
         Immunology
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      name:Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
      name:Dana Farber Cancer Institute, Boston, USA
      name:Dana Farber Cancer Institute, Boston, USA
      name:University of Chicago Comprehensive Cancer Center and Pathology, Chicago, USA
      name:University Hospital Erlangen, Erlangen, Germany
      name:University of Texas MD Anderson Center, Houston, USA
      name:Paracelsus University Hospital Nuremberg, Nürnberg, Germany
      name:University of Chicago Comprehensive Cancer Center and Pathology, Chicago, USA
      name:Sidney Kimmel Comprehensive Cancer Center, Baltimore, USA
      name:University of Chicago Comprehensive Cancer Center and Pathology, Chicago, USA

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