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52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block | Arthritis Research & Therapy
Description:
Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren
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mothers, antibodies, sera, peptides, lupus, group, article, pubmed, heart, peptide, study, google, scholar, pregnancy, groups, igg, block, reactivity, cas, congenital, tested, elisa, chb, patients, proteins, antigens, children, weeks, reacting, neonatal, samples, table, data, rossa, positive, protein, versus, figure, recognized, residues, important, sle, fetal, number, disease, antigen, observed, risk, level, receptor,
Topics {âïž}
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Questions {â}
- Li JM, Horsfall AC, Maini RN: Anti-La (SS-B) but not anti-Ro52 (SS-A) antibodies cross-react with laminin â a role in the pathogenesis of congenital heart block?
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headline:52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block
description:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13â24 residues long, of Ro52/Ro60 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sjögren's syndrome and asymptomatic mothers of group I, who had at least one infant with neonatal lupus, and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to Ro52 peptides 107â122 and 277â292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with Ro52 peptides 1â13, 277â292 and 365â382. Antibodies to Ro52 peptide 365â382 have been shown previously to cross-react with residues 165â185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these Ro52 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to Ro52 peptides 1â13, 107â122, 277â292 and 365â382 may therefore represent important biomarkers to predict a complication in pregnant lupus women with Ro52 antibodies.
datePublished:2005-11-04T00:00:00Z
dateModified:2005-11-04T00:00:00Z
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keywords:
Congenital Heart Block
British Isle Lupus Assessment Group
Neonatal Lupus
Western Blotting Test
Systematic Mapping Study
Rheumatology
Orthopedics
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headline:52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block
description:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13â24 residues long, of Ro52/Ro60 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sjögren's syndrome and asymptomatic mothers of group I, who had at least one infant with neonatal lupus, and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to Ro52 peptides 107â122 and 277â292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with Ro52 peptides 1â13, 277â292 and 365â382. Antibodies to Ro52 peptide 365â382 have been shown previously to cross-react with residues 165â185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these Ro52 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to Ro52 peptides 1â13, 107â122, 277â292 and 365â382 may therefore represent important biomarkers to predict a complication in pregnant lupus women with Ro52 antibodies.
datePublished:2005-11-04T00:00:00Z
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Congenital Heart Block
British Isle Lupus Assessment Group
Neonatal Lupus
Western Blotting Test
Systematic Mapping Study
Rheumatology
Orthopedics
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