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We are analyzing https://link.springer.com/article/10.1186/ar1848.

Title:
52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block | Arthritis Research & Therapy
Description:
Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

mothers, antibodies, sera, peptides, lupus, group, article, pubmed, heart, peptide, study, google, scholar, pregnancy, groups, igg, block, reactivity, cas, congenital, tested, elisa, chb, patients, proteins, antigens, children, weeks, reacting, neonatal, samples, table, data, rossa, positive, protein, versus, figure, recognized, residues, important, sle, fetal, number, disease, antigen, observed, risk, level, receptor,

Topics {✒}

anti-ro/ssa-positive pregnant women anti-ssa/ro52 autoantibodies blocking 52-kda ro/ssa antigen anti-ro/ssa antibodies detected anti-ro/ssa-positive patients article download pdf enzyme-linked immunosorbent assay maternal anti-ro/la antibodies cross-reactive b-cell epitope 60-kd ssa/ro protein 52-kd ro/ssa protein ssa/ro-ssb/la inactive/mildly active disease maternal anti-la idiotype 52-kda ro/ssa native 60-kd ro/ss denatured 52-kd ro/ss 52 kd ssa/ro particle react preferentially congenital heart block neonatal lupus erythematosus block receptor activation systemic lupus erythematosus cross-reactive antibodies antagonized 48-kda la/ssb western blotting assay full size image privacy choices/manage cookies putative ro52 epitopes anti-ssa antibodies b-cell epitopes autoimmune rheumatic disease western blotting tests fetal cardiac-specific antigens de carvalho ac ro/ssa autoantigens neonatal lupus syndromes complete atrioventricular block amino acid sequences service de rhumatologie authors’ original file total test antigen severely active disease anti-ro reactivity mol cell cardiol uk david human fetal heart article number r4 article fritsch la/ssb ribonucleoproteins

Questions {❓}

  • Li JM, Horsfall AC, Maini RN: Anti-La (SS-B) but not anti-Ro52 (SS-A) antibodies cross-react with laminin – a role in the pathogenesis of congenital heart block?

Schema {đŸ—ș}

WebPage:
      mainEntity:
         headline:52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block
         description:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13–24 residues long, of Ro52/Ro60 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sjögren's syndrome and asymptomatic mothers of group I, who had at least one infant with neonatal lupus, and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to Ro52 peptides 107–122 and 277–292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with Ro52 peptides 1–13, 277–292 and 365–382. Antibodies to Ro52 peptide 365–382 have been shown previously to cross-react with residues 165–185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these Ro52 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to Ro52 peptides 1–13, 107–122, 277–292 and 365–382 may therefore represent important biomarkers to predict a complication in pregnant lupus women with Ro52 antibodies.
         datePublished:2005-11-04T00:00:00Z
         dateModified:2005-11-04T00:00:00Z
         pageStart:1
         pageEnd:11
         license:http://creativecommons.org/licenses/by/2.0/
         sameAs:https://doi.org/10.1186/ar1848
         keywords:
            Congenital Heart Block
            British Isle Lupus Assessment Group
            Neonatal Lupus
            Western Blotting Test
            Systematic Mapping Study
            Rheumatology
            Orthopedics
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ScholarlyArticle:
      headline:52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block
      description:Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13–24 residues long, of Ro52/Ro60 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sjögren's syndrome and asymptomatic mothers of group I, who had at least one infant with neonatal lupus, and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to Ro52 peptides 107–122 and 277–292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with Ro52 peptides 1–13, 277–292 and 365–382. Antibodies to Ro52 peptide 365–382 have been shown previously to cross-react with residues 165–185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these Ro52 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to Ro52 peptides 1–13, 107–122, 277–292 and 365–382 may therefore represent important biomarkers to predict a complication in pregnant lupus women with Ro52 antibodies.
      datePublished:2005-11-04T00:00:00Z
      dateModified:2005-11-04T00:00:00Z
      pageStart:1
      pageEnd:11
      license:http://creativecommons.org/licenses/by/2.0/
      sameAs:https://doi.org/10.1186/ar1848
      keywords:
         Congenital Heart Block
         British Isle Lupus Assessment Group
         Neonatal Lupus
         Western Blotting Test
         Systematic Mapping Study
         Rheumatology
         Orthopedics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Far1848/MediaObjects/13075_2005_Article_1729_Fig1_HTML.jpg
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            name:Christine Fritsch
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                  name:Institut de Biologie MolĂ©culaire et Cellulaire
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                     name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
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            name:Vincent Ricchiuti
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                  name:Institut de Biologie MolĂ©culaire et Cellulaire
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                     name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
                     type:PostalAddress
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                     type:PostalAddress
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            name:Sylviane Muller
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                  name:Institut de Biologie MolĂ©culaire et Cellulaire
                  address:
                     name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
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         name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
         type:PostalAddress
      name:Brigham and Women's Hospital, Harvard Medical School
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         name:Division of Endocrinology, Diabetes & Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
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         name:Groupe Hospitalier Bichat-Claude Bernard, Service de Rhumatologie, Paris, France
         type:PostalAddress
      name:Institut de Biologie MolĂ©culaire et Cellulaire
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            name:Institut de Biologie MolĂ©culaire et Cellulaire
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               name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
               type:PostalAddress
            type:Organization
            name:Brigham and Women's Hospital, Harvard Medical School
            address:
               name:Division of Endocrinology, Diabetes & Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:David A Isenberg
      affiliation:
            name:University College London
            address:
               name:Centre for Rheumatology, The Middlesex Hospital, University College London, UK
               type:PostalAddress
            type:Organization
      name:Olivier Meyer
      affiliation:
            name:Service de Rhumatologie
            address:
               name:Groupe Hospitalier Bichat-Claude Bernard, Service de Rhumatologie, Paris, France
               type:PostalAddress
            type:Organization
      name:Sylviane Muller
      affiliation:
            name:Institut de Biologie MolĂ©culaire et Cellulaire
            address:
               name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
      name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
      name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
      name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France
      name:Division of Endocrinology, Diabetes & Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
      name:Centre for Rheumatology, The Middlesex Hospital, University College London, UK
      name:Groupe Hospitalier Bichat-Claude Bernard, Service de Rhumatologie, Paris, France
      name:UPR 9021 Centre National de la Recherche Scientifique, Institut de Biologie MolĂ©culaire et Cellulaire, Strasbourg, France

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