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Title:
The changing metabolic landscape of bile acids – keys to metabolism and immune regulation | Nature Reviews Gastroenterology & Hepatology
Description:
Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate inflammation, and they serve as signalling molecules that regulate appetite and energy homeostasis. The observation that there are hundreds of bile acids, especially many amidated bile acids, necessitates a revision of many of the classical descriptions of bile acids and bile acid enzyme functions. For example, bile salt hydrolases also have transferase activity. There are now hundreds of known modifications to bile acids and thousands of bile acid-associated genes, especially when including the microbiome, distributed throughout the human body (for example, there are >2,400 bile salt hydrolases alone). The fact that so much of our genetic and small-molecule repertoire, in both amount and diversity, is dedicated to bile acid function highlights the centrality of bile acids as key regulators of metabolism and immune homeostasis, which is, in large part, communicated via the gut microbiome. Bile acids have important roles in human metabolism and immune regulation. In this Perspective, Dorrestein and colleagues discuss the technologies and data science-related approaches that are improving our understanding of the diversity of bile acids and their multifaceted roles.
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privacy policy nature portfolio journals 4-seco-12α-hydroxy-5β-cholan-3 nature portfolio data-independent ms/ms deconvolution gas-liquid chromatography-mass spectrometry advertising amino acid n-acyltransferase social media lipid research smith–lemli–opitz syndrome research progress reduce graft-versus-host disease liquid chromatography-mass spectrometry bile-acid-mediated decrease spectral libraries gas chromatography-mass spectrometry polycystic ovary syndrome microbiota-gut-brain-liver axis research 3β-hydroxy bile acids org/data/structure/download scientific reprints hepatic cholesterol 7ɑ-hydroxylase human ntn-hydrolase superfamily bile acid n-acetylglucosaminidation 6α-hydroxy bile acids short-chain fatty acids 7α-hydroxysteroid dehydratase hsh2 chronic fatigue syndrome nuclear receptors sxr/pxr n-acyl glycyltaurine conjugate alkaloid-sequestering poison frogs gut microbiome-linked metabolites chemical language microbiota-derived bile acids cross-sectional karmen study mass spectrometry data molecular-formula-oriented method extracellular matrix-related genes microbial bile-acid conjugates van der hooft amine-conjugated bile acids universal language positive/negative ion-switching publishing agreement high resolution lc/ms 7α-hydroxyl bile salts high-confidence structural annotation
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- Biotransformation of waste bile acids: a new possible sustainable approach to anti-fungal molecules for crop plant bioprotection?
- Cholesterol metabolism pathways – are the intermediates more important than the products?
- Middle-distance running acutely influences the concentration and composition of serum bile acids: potential implications for cancer risk?
- Targeting the gut-skin axis – probiotics as new tools for skin disorder management?
- Taurine: a conditionally essential amino acid in humans?
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