We are analyzing https://link.springer.com/article/10.1186/s13024-022-00548-6.

Title:
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia | Molecular Neurodegeneration
Description:
A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.
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Keywords {🔍}

pubmed, google, scholar, article, cas, cognitive, gut, central, brain, disease, acid, alzheimers, microbiota, decline, tryptophan, tmao, metabolites, function, role, mice, acids, barrier, bile, human, microbial, risk, levels, pathway, axis, aging, liver, microbiome, metabolism, bbb, cell, studies, metabolic, cns, impairment, patients, nature, publishing, wang, intestinal, cells, serotonin, study, factor, cognition, bloodbrain,

Topics {✒️}

activate n-methyl-d-aspartate amyloid beta-peptide-induced apoptosis n-methyl-d-aspartate receptor liquid chromatography/mass spectrometry short-chain fatty-acid binding blood trimethylamine-n-oxide originates n-methyl-d-aspartate nr sirt3-sod2-mtros signaling pathway plasma trimethylamine-n-oxide levels short-chain fatty acids blood–cerebral-spinal fluid barrier amyloid-β1-42-induced rat model anti-inflammatory p-glycoprotein pathway gwenaelle le gall p-cresol-producing intestinal bacteria microbial-dependent metabolite generated sense microbiota-derived indoles p-cresyl sulfate affects serum trimethylamine-n-oxide pérez-de la cruz mass spectrometry-based metabolomics microbiota-gut-brain axis disorders app/ps1 double-transgenic mice mitogen-activated protein kinases hypothalamic-pituitary-adrenal axis major phenylpropanoid-derived metabolites microbiota-gut-liver-brain axis microbiota-gut-brain-liver axis 13c-labeled dietary fibers large-scale transcriptomics analysis article download pdf understanding brain-gut-microbiome connections mitogen-activated protein kinase gut microbiota-dependent metabolite microbiota-derived metabolite contribution e2f-1/p53/bax pathway [136 e2f–1/p53/bax pathway explore critical connections emerging microbial-derived metabolites decreased resting-state activity brain-derived neurotropic factor microbial-derived bioactive metabolites gut-brain axis encompasses cholecystokinin-stimulated pancreatic secretion long-term spermidine-rich treatment trimethylamine-n-oxide trimethylamine n-oxide microbial-derived phenolic compounds david vauzour increase tau-induced polymerization

Questions {❓}

Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?
Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier?
Healthy Aging and Dementia: Two Roads Diverging in Midlife?
Mechanism of acute tryptophan depletion: is it only serotonin?
Neuronal mitophagy: friend or foe?
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
What has serotonin to do with depression?

Schema {🗺️}

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         headline:Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
         description:A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.
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      headline:Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
      description:A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.
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         Tryptophan
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         Neurology
         Molecular Medicine
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      name:Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich, UK
      name:APC Microbiome Ireland, University College Cork, Cork, Ireland
      name:Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
      name:APC Microbiome Ireland, University College Cork, Cork, Ireland
      name:Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland
      name:Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich, UK
      name:Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich, UK

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